Hydrocortisone is a mild corticosteroid (steroid) medication that helps reduce inflammation, redness, itching, and swelling. It is commonly used to treat various skin conditions such as eczema, psoriasis, contact dermatitis, and insect bites. When used appropriately, Hydrocortisone can significantly improve skin irritation and restore comfort.

Cortisone and Hydrocortisone are both corticosteroids, but there’s a subtle difference. Hydrocortisone is the active form of Cortisone. In the body, Cortisone is converted into Hydrocortisone (also known as cortisol), which then exerts its anti-inflammatory effects. Medically, Hydrocortisone is often preferred in topical treatments and hormone replacement therapy because it’s more active and effective than Cortisone.

The choice between Hydrocortisone cream and ointment depends on the condition and area of application. Creams are typically better for moist or weepy skin areas, such as eczema on the face or folds of the skin. Being thicker and greasier, ointments are more effective for dry, scaly patches like psoriasis or chronic dermatitis. If you’re unsure which formulation to use, consult a licensed physician at Your Doctors Online to get a personalized Hydrocortisone prescription suited for your skin concern.

Hydrocortisone is commonly prescribed to manage mild to moderate skin conditions that involve inflammation or irritation. These include:

• Eczema
• Psoriasis
• Atopic dermatitis
• Allergic reactions
• Seborrheic dermatitis
• Insect bites or stings
• Rash from poison ivy or oak
• Anal itching or hemorrhoids (in some formulations)
  
  

You can also explore alternatives like Triamcinolone for more severe inflammation.

Hydrocortisone should not be used on:

• Open wounds or infected skin (e.g., untreated fungal, viral, or bacterial infections)
• Acne or rosacea
• Eyes or eyelids
• Genital or rectal areas, unless directed by a doctor

Your Doctors Online provides 24/7 guidance on safe steroid use and alternative options like antifungal creams (e.g., Clotrimazole) if needed.

The main difference is the base: creams are water-based and absorb quickly, making them ideal for oozing or moist skin areas. Ointments are oil-based and provide a barrier that traps moisture, making them more suitable for dry, thickened skin. The same explanation applies to Hydrocortisone cream and ointment.

If Hydrocortisone isn’t suitable for your skin or condition, alternatives may include:

• Non-steroidal creams like calcineurin inhibitors (e.g., Tacrolimus or Pimecrolimus)
• Moisturizers with ceramides for eczema-prone skin
• Natural remedies like colloidal oatmeal, aloe vera, or calendula (milder, but less potent)
• Antihistamine creams for itching

Yes, Hydrocortisone 2.5% is considered a prescription-strength topical steroid. It is stronger than the commonly available 0.5% or 1% over-the-counter versions. It’s typically prescribed for moderate skin conditions that don’t respond to lower strengths. Because of its potency, it should be used under medical supervision to avoid skin thinning or other side effects.

Yes, 1% hydrocortisone cream is available over the counter (OTC) in both the U.S. and Canada. It’s often used for mild itching, insect bites, or irritation. However, higher strengths like Hydrocortisone 2.5% or treatment for sensitive areas may require a prescription.