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Get an Opzelura (Ruxolitinib) prescription refill online

You can get an Opzelura (Ruxolitinib) prescription refill (1.5% topical cream) online to treat mild to moderate eczema (atopic dermatitis).

Getting an Opzelura (Ruxolitinib) prescription refill from us is straightforward and effortless; you can connect with a qualified doctor anytime through “Your Doctors Online” to discuss your presenting symptoms. However, an Opzelura (Ruxolitinib) prescription will only be provided after consultation with our qualified doctor and if the treatment is entirely safe for your unique needs.

What is Opzelura?

Opzelura is a brand name for the generic ruxolitinib that belongs to the class of kinase inhibitors prescribed in the topical dosage form, mostly for the effective treatment of eczema, especially in immunocompromised patients. This medication works by stopping the further growth of cells from treating the disease.

Uses of Opzelura (Ruxolitinib)

Opzelura treats diseases, including myelofibrosis, bone marrow disorders, and eczema, especially atopic dermatitis. It is usually prescribed topical to be applied on the affected area for effective direct treatment.
This medication is also prescribed to be used for polycythemia Vera (blood cancer) and graft-versus-host disease, which is a complication that can occur after a stem cell or bone marrow transplant.

How does Opzelura work?

Ruxolitinib is a Janus kinase (JAK) inhibitor, or just kinase inhibitor, which works by interfering with the activity of JAK proteins that regulate blood cell production. This medication stops the protein enzyme tyrosine kinase and stops cell growth or reproduction.

It has been approved for use in myelofibrosis, polycythemia vera, and some instances of acute graft-versus-host disease. The FDA approves it for the short-term and non-continuous treatment of mild to moderate atopic dermatitis.

What are the different dosage forms and strengths of Opzelura?

Opzelura comes in two different dosage forms: Tablets and Topical creams. Usually, in the topical cream form, it is available in strength 1.5% cream, while in oral or tablet dosage forms, it comes in different strengths, including 5 mg,15 mg, and 20 mg.

How to take Opzelura?

For the treatment of any cancer-related health condition like myelofibrosis (bone marrow disorders), a typical dosage routine involves starting with a lower dose and gradually increasing it as tolerated by the patient. 

Topical cream, available in 5% Ruxolitinib, can only be applied 2 -3 times a day per the severity and nature of your medical condition. 

Side effects of Opzelura (Ruxolitinib)

Common Side Effects of Opzelura (Ruxolitinib):

  • Upper respiratory tract infections
  • Bruising
  • Headache
  • Anemia
  • Thrombocytopenia
  • Nausea
  • Vomiting
  • Diarrhea
  • Fatigue
  • Abdominal pain
  • Peripheral edema
  • Dizziness
  • Increased levels of pancreatic enzymes
  • Muscle spasms

Severe Side Effects:

  • Severe infections
  • Bleeding
  • Liver problems
  • Cardiovascular events
  • Hypertension
  • Cytopenias
  • Gastrointestinal perforations
  • Nervous system effects

Request Opzelura prescription refill

Get a prescription refill for Opzelura in three easy steps.


Describe your issue

Download our app, register and tell us about your medical issue to get started.

  • Eczema
  • Anemia
  • STD
  • UTI
  • Skin
  • Covid


Chat with a doctor

Connect with a board-certified doctor. You can chat, send pictures and videos.

Hi I’m Dr. Nicole. How may I help you?

Hi Dr. Nicole, I have atopic dermatitis . Can I get some form of treatment, please?


Get prescription refill

Our online doctors can help you with your medical issues and give you prescriptions.


  • Ruxolitinib 5% topical cream,
  • twice a day

Send Prescription

Prevention and ContraIndications

  • Share your medication history with your healthcare provider to avoid hypersensitivity or allergic reactions. 
  • In case of any liver problems or medical history, share it with your doctor and pharmacist to get the adjusted dose or an alternative medication to treat your medical condition. 
  • Monitor the cardiac and rhythmic changes after taking this medication and inform your provider of any unusual changes or effects. 
  • Discuss your non-prescription medication if you are taking to avoid any drug-drug interactions.

FAQs about Opzelura prescription refill

How does Opzelura (Ruxolitinib) work for vitiligo?

Opzelura (Ruxolitinib) helps with vitiligo by calming down the immune system, preventing it from harming the cells that create skin color, also called pigment-producing cells (melanocytes). This can slow or stop vitiligo and encourage the return of natural skin color.

How long does 60 grams of Opzelura last?

Doses and dosage forms are decided according to the nature and severity of the medical condition, Similarly,60g of Opzelura can last varying durations depending on the prescribed dosage and frequency of use. Following your healthcare provider’s instructions for accurate usage is essential for effective treatment.

What happens if I miss a dose?

In case of missing the dose, in either cream or tablet, it’s good to take it as soon as you remember it, remembering that it’s not the time for the next prescribed dose. In case it is, skip the previous and take the next dose. Avoid overdosing at all costs to avoid any unwanted side effects.

Are there any interactions with Opzelura (Ruxolitinib)?

Opzelura (Ruxolitinib) has some significant interactions, including live vaccines.
And herbal products that should be avoided when taking these medications. Some of the other medications that should not be taken when on opzelura include ketoconazole, rifampin, and cyclosporin.

Your Doctors Online uses high-quality and trustworthy sources to ensure content accuracy and reliability. We rely on peer-reviewed studies, academic research institutions and medical associations to provide up-to-date and evidence-based information to the users.

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