Get a Wellbutrin (Bupropion) prescription refill online
Are you struggling to quit smoking and require support? You can now refill Bupropion online for smoking cessation and depression with Your Doctors Online. Our online doctor will determine the best treatment plan for you. Please know that a Wellbutrin refill will only be provided after a consultation with our doctor and if the medication is appropriate for you.
- For the management of seasonal affective disorder and major depressive disorder
- Aids in smoking cessation
- Get mental health support alongside
Trusted by millions for instant online care
Over 1 million Patients
5-star Doctor Ratings
4.8 Rating
20k+ App Reviews
4.6 Rating
1k+ Trustpilot Reviews
Fill your Wellbutrin prescription with Your Doctors Online quickly
Our efficient system allows a seamless delivery of your online prescriptions.
Choose your local pharmacy
You can choose any pharmacy near you, and once your doctor approves it, we will send your prescription electronically within minutes.
Same-day prescription pickup
E-prescriptions are sent straight to your pharmacy, so in most cases you can pick up your medication the same day.
Real-time prescription tracking
Track your prescriptions and pick them up on time.
How to get a Wellbutrin prescription online
We have got the simplest signing-up process to ensure that you get the best medical care as soon as possible:
Start your visit
Download the Your Doctors Online app and register. Discuss your symptoms with our virtual doctor.
Consult a doctor
Chat live with a licensed physician at your convenience at any time of the day and from anywhere.
Get Bupropion online
If Bupropion is right for you, your doctor issues your prescription and sends it directly to your pharmacy within minutes.
Who is eligible for a Wellbutrin prescription?
Our doctor will ask about your symptoms, health history, and current medicines to decide whether Wellbutrin is right for you.
An online visit may be a good fit if
Wellbutrin may not be safe for you if you
If you’re having thoughts of suicide or self-harm, call or text 988 (Suicide & Crisis Lifeline) or call 911 right away.
How is Wellbutrin different from SSRIs?
Wellbutrin and SSRIs (such as Zoloft, Prozac, and Lexapro) both treat depression, but they work differently and have different side effects.
| Wellbutrin (Bupropion) | SSRIs | |
|---|---|---|
| How it works | Boosts norepinephrine and dopamine | Boosts serotonin |
| Sexual side effects | Rare | Common |
| Weight | Weight neutral, or may cause some weight loss | May cause weight gain |
| Energy and sleep | Can feel energized and may cause trouble sleeping | Can cause tiredness |
| Anxiety | Not approved for anxiety, and may cause jitteriness at first | Several are approved for anxiety |
| Quitting smoking | Approved to help (as Zyban) | Not used for this |
| Main safety concern | Seizures, especially at high doses | Serotonin-related side effects |
Doctors sometimes prescribe both together, adding Wellbutrin to an SSRI to boost the effect or offset sexual side effects. Your doctor can help you decide which option fits you best.
What is Wellbutrin (Bupropion) and what does it treat?
Wellbutrin, also known by its generic name Bupropion, is an atypical antidepressant. It’s classified as a norepinephrine and dopamine reuptake inhibitor (NDRI). It’s sold under the brand names Wellbutrin SR, Wellbutrin XL, Aplenzin, Forfivo XL, and Zyban (for smoking cessation).
Wellbutrin
Bupropion generic · Wellbutrin SR, XLDosages and Strengths of Wellbutrin
It is available in different dosage forms:
- Immediate-release tablets: 75 mg and 100 mg, usually taken three times a day
- Sustained-release tablets (SR): 100 mg, 150 mg, and 200 mg, usually taken twice a day
- Extended-release tablets (XL): 150 mg, 300 mg, and 450 mg, taken once a day in the morning
- Aplenzin (bupropion hydrobromide, extended-release): 174 mg, 348 mg, and 522 mg, taken once a day
- Zyban (sustained-release): 150 mg, for quitting smoking
Swallow SR and XL tablets whole; don’t crush, chew, or split them. Take your doses at least 8 hours apart if you’re on SR, and avoid taking it close to bedtime, since it can cause trouble sleeping. Don’t take more than your doctor prescribes, because higher doses raise the risk of seizures.
How much does a Wellbutrin prescription cost?
1. Prescription cost
A Wellbutrin prescription through Your Doctors Online starts from $20/month with our consultation plan. This covers your visit with a licensed doctor, new prescriptions or refills, dose adjustments, and follow-up messages during the month. You can cancel anytime.
2. Medication cost
- Without insurance: generic Bupropion XL (once daily) costs about $6–$35 for a 30-day supply at the cash price, depending on your dose and pharmacy. Generic Bupropion SR (twice daily) costs about $19–$37 for a month.
- With insurance: most plans cover generic Bupropion, usually for a small copay.
- Brand vs generic: brand-name Wellbutrin XL, Wellbutrin SR, Aplenzin, and Zyban cost much more than the generic.
3. Total cost
For most people taking generic Bupropion, the total monthly cost is about $26–$57. That’s $20 for the prescription plus about $6–$37 for the medicine, and it can be lower with insurance or by comparing pharmacies.
Side effects of Wellbutrin
Common side effects may include:
- Trouble sleeping
- Dry mouth
- Headache
- Nausea
- Agitation or anxiety
- Dizziness
- Tremor
- Sweating
- Constipation or diarrhea
- Weight loss or loss of appetite
Some serious side effects of Wellbutrin to look out for include:
- Seizures for which the risk is higher at high doses or in people with seizure risk factors
- Mood and behavior changes: agitation, hostility, unusual thoughts, or mania (racing thoughts, very high energy)
- High blood pressure
- Chest pain, pounding heartbeat, or fainting
- Eye pain or vision changes: a sign of angle-closure glaucoma
- Severe allergic or skin reactions: rash, hives, blistering, swelling, or trouble breathing
- Ringing in the ears, or a severe headache
Stop taking Wellbutrin and get medical help right away if you have a seizure or any other serious side effect. In an emergency, call 911 or call or text 988.
Meet our online doctors in the United States
Dr. Stotland Mitchell is a board-certified Occupational Medicine physician with 5+ years of experience. He provides virtual care across all U.S. states and D.C., blending allopathic medicine with public health insights. His approach focuses on rapid symptom relief and long-term prevention, often resulting in faster recovery and improved health outcomes for his patients.

Dr. Richard Honaker is a board-certified physician with more than 40 years of experience in family and emergency medicine. He serves as Chief Medical Advisor at Your Doctors Online and is affiliated with Medical City Plano in Texas. Recognized multiple times by D Magazine and Texas Monthly, Dr. Honaker provides evidence-based care across a wide range of conditions including diabetes, hypertension, and injury care.

Dr. Monique Rainford is an OB/GYN expert and Assistant Clinical Professor at Yale School of Medicine. With 25+ years of experience, she’s led OB/GYN departments at Yale Health and Baltimore Medical System. Her clinical interests include pregnancy, menstrual health, chronic pelvic conditions, and lifestyle medicine. Dr. Rainford advocates for maternal health equity, especially in underserved communities.

Dr. Candice Fraser is an OB/GYN practitioner and founder of Trinity Medical Care. With over a decade of experience, she focuses on reproductive care, menstrual health, and menopause management. Along with medical training and residency, she also holds an MBA in healthcare management, blending business insight with clinical excellence.
Dr. Danielle DonDiego is a double board-certified Family and Obesity Medicine physician, business mentor, and author of Self-Care Rx. She focuses on helping patients manage weight, improve nutrition, and adopt sustainable lifestyle changes. A graduate of the Virginia College of Osteopathic Medicine with an MBA from Virginia Tech, she combines her medical expertise with a passion for patient education and long-term wellness.
Dr. Amber Robins is a double board-certified Family and Lifestyle Medicine physician with a strong focus on women’s health, preventive care, and patient advocacy. She earned her MD from the University of Rochester and an MBA from LSU-Shreveport. A published author and media contributor, she blends clinical expertise with a passion for empowering patients to make informed health decisions.
Dr. Nina Carroll is a retired OB/GYN with decades of experience serving women in the U.S. and abroad. She specialized in menopause care, sexual health, and trauma-informed women’s health. Today, she continues her work through medical writing, focusing on sexual minority women’s health and care for survivors of trauma.
Dr. Nerissa Bauer is a behavioral pediatrician specializing in ADHD, parenting strategies, and mental health in children. A former academic and AAP spokesperson, she is the creator of the TEACH Me ADHD program, helping families better understand and manage ADHD. She brings warmth, creativity, and evidence-based guidance to her work with patients and parents.
Frequently asked questions
Can you get Wellbutrin over the counter?
Wellbutrin is a prescription medication that is not available for use over the counter. To obtain a Wellbutrin, you will need an online prescription from a licensed healthcare provider.
How to get a prescription refill without seeing a doctor?
You can get a Wellbutrin prescription refill online without seeing a doctor via the Your Doctors Online app. One of our qualified healthcare professionals will evaluate your need for Wellbutrin before prescribing a refill.
Who should not take Wellbutrin(Bupropion)?
Wellbutrin (Bupropion) is contraindicated in patients with anorexia, bulimia nervosa, and seizure disorder. It is also recommended to use it carefully in people with hypertension, diabetes, and bipolar disorder. People who have an allergy to any of its ingredients or have recently stopped using seizure medications, alcohol, or any sedatives should avoid taking Wellbutrin.
What should you avoid when taking Wellbutrin?
If you are taking Wellbutrin (Bupropion), avoid taking alcohol, MAO inhibitors, and other medications, including Phenobarbitals, Ritonavir, Lopinavir, Nelfinavir, and Efavirenz.
What happens if you miss a dose of Wellbutrin?
If you forget to take your Wellbutrin (Bupropion), it is recommended to take the missed dose as soon as possible. But if it’s nearly time for your next dose, just go ahead and skip the one you missed. Stick to your usual dosing routine.
What can I try instead of Wellbutrin?
If you can not take Wellbutrin for some reason, there are other alternative medications you can count on. At our telehealth platform, we offer the following Selective Serotonin Reuptake Inhibitors (SSRIs)
Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs) that may be prescribed include:
Tricyclic anti-depressants, MAOIs, and other atypical antidepressants may also be prescribed instead of Wellbutrin. For smoking cessation, generic Varenicline prescription may also be given through online telehealth platform.
What happens if I take a lot of Wellbutrin?
Overdosing on Wellbutrin can increase the risk of seizures, loss of consciousness, and hallucinations and can cause agitation, fever, heartbeat, and confusion.
How fast is the weight loss on Wellbutrin XL?
Weight loss can vary from individual to individual. Some people have reported that they lost weight within 1-2 weeks of taking the medicine while others have reported weight loss after using Wellbutrin for consecutive 8 weeks.
Is Wellbutrin a stimulant?
Wellbutrin is not classified as a stimulant but is sometimes prescribed for ADHD.