How does Progesterone work for men?

Progesterone for men
Medically reviewed by Richard Honaker M.D.


While commonly associated with women’s health, progesterone is pivotal in maintaining hormonal balance and overall well-being in men. Beyond its role as a precursor to testosterone, progesterone influences essential physiological processes such as bone density regulation, blood sugar maintenance, and cognitive function. Inadequate progesterone levels in men can lead to “estrogen dominance,” contributing to symptoms like erectile dysfunction, fatigue, and decreased libido. Under healthcare professionals’ guidance, progesterone supplementation offers a potential solution to restore hormonal balance and reduce symptoms associated with progesterone deficiency, ultimately promoting optimal health and vitality in men.

How does progesterone work?

The mechanisms behind progesterone’s function in men’s health are crucial for grasping its significance in maintaining hormonal balance. Here is how it works:

Alcohol Consumption and Progesterone Levels

Alcohol consumption elevates blood estrogen levels and negatively impacts progesterone production in men. Even moderate drinking can decrease zinc absorption, further exacerbating progesterone deficiency. This interconnected relationship underscores the importance of lifestyle factors in regulating hormone levels and maintaining overall health.

Weight Gain and Progesterone Imbalance

Low progesterone levels are often associated with weight gain, perpetuating a cycle of hormonal imbalance. Excess weight contributes to decreased progesterone production and exacerbates estrogen dominance, particularly in the presence of thyroid dysfunction. This interplay highlights the importance of addressing underlying health issues to promote hormonal balance and treat inflammation-related complications.

What happens if a man takes progesterone?

Progesterone plays a crucial role in maintaining normal health in men, balancing the following health aspects:

  1. Fertility and sperm function: Progesterone is crucial in male fertility by facilitating sperm function and maturation. Its influence extends beyond reproductive health, directly affecting the cardiovascular, nervous, and skeletal systems. Moreover, progesterone is recognized for its neuroprotective properties and potential therapeutic applications in conditions like cerebral edema, Alzheimer’s disease, diabetic neuropathy, and osteoporosis.
  1. Diverse physiological effects: Progesterone exerts a broad range of effects on men’s health, including regulation of testosterone production, sperm maturation, and central nervous system function. Additionally, it impacts sleep quality, behavior, immunity, kidney function, respiratory health, appetite regulation, adipose tissue metabolism, and weight regulation.
  1. High progesterone levels and metabolic health: Studies indicate that serum progesterone levels may influence metabolic health, particularly blood glucose regulation. Higher progesterone levels have been associated with elevated fasting blood glucose, HbA1C levels, and reduced beta cell function. Increased incidence of prediabetes and type 2 diabetes mellitus (T2DM) has been observed in individuals with higher progesterone levels, which highlights the importance of hormonal balance in metabolic regulation.
  1. Risk Factors with low progesterone levels: When coupled with low estradiol, low progesterone levels pose a significant risk factor for aortic abdominal aneurysms in men. Hormonal imbalance characterized by insufficient progesterone levels may lead to an increase in estrogen production, triggering adverse effects such as weight gain, muscle mass loss, gynecomastia (development of male breast tissue), decreased libido, erectile dysfunction, prostate enlargement, and increased susceptibility to certain cancers.

What are the symptoms of low progesterone in men?

Some common symptoms may indicate progesterone deficiency or estrogen dominance:

  1. Physical appearance: Estrogen dominance may manifest in physical changes such as baldness, alterations in body odor, breast growth (gynecomastia), and reduced muscle development. However, it’s crucial to note that these symptoms can be multifactorial, and low progesterone levels may contribute to but not exclusively cause these outcomes.
  1. Psychological symptoms: Low progesterone levels can impact mood and mental well-being, leading to symptoms like depression, mood swings, and anxiety. These psychological symptoms may be indicative of hormonal imbalance and warrant further evaluation and intervention.
  1. Sexual dysfunction: Progesterone deficiency may manifest in sexual dysfunction, including low sex drive (libido) and erectile dysfunction. These symptoms can significantly impact the quality of life and intimate relationships, highlighting the importance of addressing underlying hormonal imbalances.
  1. Muscle mass loss and fatigue: Reduced progesterone levels may contribute to muscle mass loss and fatigue in men. Decreased muscle strength and endurance, persistent fatigue, and difficulty concentrating can impair daily functioning and overall vitality.

If you’re experiencing any of these symptoms, it’s advisable to seek medical evaluation. Early detection and management of low progesterone levels can help alleviate symptoms and promote overall health and well-being.

What are the benefits of men taking progesterone?

Progesterone isn’t just vital for women’s health and crucial in enhancing men’s overall well-being and vitality. 

  • Sperm production: Progesterone supports sperm production, contributing to male fertility and reproductive health.
  • Mood regulation: Progesterone plays a role in regulating mood and emotional