Amoxicillin for UTI: Dosage, treatment and side effects

Amoxicillin for UTI
Medically reviewed by Dr. Devindra Bhatt


Are you experiencing a burning sensation during urination or a constant urge to visit the bathroom? These could be signs of a urinary tract infection (UTI). The good news: Amoxicillin, a common antibiotic, might be your ally in fighting UTIs. This blog will explore how amoxicillin tackles bacteria causing UTIs to the right dosage, what to do if you miss a dose, and signs that the medication works. We also shared insights on allergies, precautions, and when it’s crucial to see a doctor. 

Can Amoxicillin treat UTI?

Urinary tract infections (UTIs) can be triggered by various germs, including bacteria, fungi, and, in rare instances, viruses. However, bacterial UTIs are the most prevalent. While the common perception of a UTI often revolves around a bladder infection (cystitis), it’s essential to recognize that UTIs encompass a range of types, such as kidney infections (pyelonephritis) and urethral infections (urethritis).

When bacteria are identified as the root cause of a UTI, the sole effective treatment is antibiotics. Antibiotics designed for UTIs either inhibit bacterial growth or eradicate the bacteria.

UTIs have the potential to induce infection and inflammation. Physicians often recommend antibiotics like amoxicillin to address urinary tract infections (UTIs) and alleviate symptoms. If you’re prescribed amoxicillin for a UTI, you should start experiencing relief within a few days as the medication takes effect.

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How does Amoxicillin work for UTI?

Amoxicillin, often in combination with potassium clavulanate (Augmentin), belongs to the penicillin class of antibiotics. Notably, cefdinir (Omnicef) and cephalexin (Keflex) fall into a distinct antibiotic class closely related to penicillins.

The efficacy of these antibiotics lies in their ability to eradicate bacteria by targeting a fundamental component—the cell wall. In the case of amoxicillin/potassium clavulanate, it is important to note that it may not always be the primary choice due to concerns about antibiotic resistance. However, for certain individuals, this combination can prove effective.

Understanding the mechanism of destroying bacterial cell walls offers insight into their effectiveness in combating UTIs. This knowledge underscores the importance of healthcare providers making informed choices based on individual circumstances, ensuring the optimal treatment approach for each patient.

Treating Urinary Tract Infections with Amoxicillin


Determining the appropriate dosage of antibiotics is crucial for successfully treating urinary tract infections (UTIs). The typical dosage is 500 mg taken every 8 hours or 875 mg every 12 hours for 4-7 days. It’s important to adhere to your healthcare provider’s recommendations for optimal results.

Additionally, for specific conditions such as gonorrhea and H. pylori infection, distinct doses are prescribed. Adhering to the recommended dosage and treatment duration is essential for ensuring the effectiveness of amoxicillin and associated antibiotics in combating UTIs. Always consult with your healthcare provider to determine the most suitable course of treatment for your case.

Missed Dose

If you miss a dose of this medication, take it as soon as you remember. However, if your next scheduled dose is approaching, you should skip the missed dose and resume your regular dosing schedule. Avoid doubling up on doses to compensate for a missed one.

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How to Take It?

Follow your doctor’s instructions precisely when taking this medication. Refrain from exceeding the prescribed dosage, taking it more frequently, or extending the duration beyond your doctor’s recommendation. This medicine can be taken with or without food. For those using the oral liquid form:

  • Ensure the bottle is well-shaken before each use.
  • Measure the dose using a marked measuring spoon, oral syringe, or medicine cup.
  • Avoid using an average household teaspoon, as it may not provide the accurate amount of liquid.
  • Continue using the medication for the full duration of the prescribed treatment, even if you begin to feel better after the initial doses. Interrupting the treatment prematurely may result in incomplete resolution of the infection. 

If You Take Too Much

In case of a potential overdose, where symptoms may not be significant at less than 250 mg/kg but can lead to kidney failure in higher-dose instances, contact your doctor immediately. It’s important to be cautious about antibiotic overuse, as even with the best intentions, it can have serious short-term effects on the body. Overuse may lead to dysbiosis—a disruption of the bacteria in the gut—resulting in symptoms such as upset stomach, bloating, diarrhea, and constipation. Always prioritize the prescribed regimen and consult your healthcare provider if you have concerns or questions about your medication.

Interactions with other medications

While certain medications should not be used together, there are cases where your healthcare provider may prescribe two different medicines despite potential interactions. Your doctor may adjust the dosage or recommend other precautions. 

Using this medicine in conjunction with the following medicines is generally not recommended, although there may be exceptions. If your doctor prescribes both medicines simultaneously, they may modify the dosage or frequency of use for one or both medications.

  • Chlortetracycline
  • Cholera Vaccine
  • Demeclocycline
  • Desogestrel
  • Dienogest
  • Doxycycline
  • Drospirenone
  • Eravacycline
  • Estradiol
  • Ethinyl Estradiol
  • Ethynodiol
  • Gestodene
  • Levonorgestrel
  • Lymecycline
  • Meclocycline
  • Mestranol
  • Methacycline
  • Methotrexate
  • Minocycline
  • Mycophenolate Mofetil
  • Nomegestrol
  • Norethindrone
  • Norgestimate
  • Norgestrel
  • Oxytetracycline
  • Rolitetracycline
  • Sarecycline
  • Sulfasalazine
  • Tetracycline
  • Tigecycline
  • Venlafaxine
  • Warfarin

Using this medicine concurrently with the following medicines may elevate the risk of specific side effects. However, your doctor may determine that the benefits of using both drugs outweigh the potential risks. If both medicines are prescribed, your doctor may adjust the dosage or frequency of use for one or both medications.

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Who can and cannot take amoxicillin?

Amoxicillin is a medication that may not be suitable for everyone. To ensure its safety for your specific circumstances, it is crucial to inform your doctor if you:

Have Experienced Allergic Reactions

If you have ever had an allergic reaction to amoxicillin, penicillin, or any other medication, it is vital to communicate this to your healthcare provider. Allergic reactions can vary in severity, and your doctor will assess the risk factors before prescribing amoxicillin.

Have Liver or Kidney Problems:

Individuals with liver or kidney problems should inform their doctor about their medical history. Adjustments to the dosage or the choice of medication may be necessary to ensure the safety and effectiveness of amoxicillin in such cases.

Other Considerations:

While the above points are specific, providing your doctor with a comprehensive medical history, including any pre-existing health conditions, ongoing medications, or allergies, is essential. This information aids in personalized treatment planning and ensures that amoxicillin is your most suitable option, and the other option for UTI is Cefdinir.

How long should I take Amoxicillin?

Your healthcare provider determines the duration of your amoxicillin treatment which is contingent upon the nature of the infection being addressed. Here are general guidelines regarding the frequency and duration of amoxicillin intake:

Frequency of doses

Depending on your doctor’s prescription, you will typically take amoxicillin either once every 8 hours or once every 12 hours. If prescribed twice daily, doses are spaced 12 hours apart. For thrice-daily prescriptions, doses are administered approximately every 8 hours.

Duration of treatment

Amoxicillin is commonly prescribed for a duration of 10 to 14 days. This timeframe ensures the effective elimination of the infection and minimizes the risk of its recurrence.

For most infections, you should start experiencing improvement within a few days of initiating amoxicillin treatment. However, completing the full course is crucial to prevent the re-emergence of the infection and ensure its complete eradication.

Why should I take the full dose?

Completing the full prescribed dose of antibiotics is crucial for several reasons, as it contributes to the effectiveness of the treatment and helps safeguard against potential complications:

Complete eradication of bacteria

Taking antibiotics consistently until the prescription is finished ensures that all bacteria causing the illness are either killed or prevented from multiplying. This comprehensive approach is vital for eliminating the entire bacterial population responsible for the infection.

Prevention of resistant bacteria

Even if symptoms improve, bacteria may still be present in the body. Stopping treatment prematurely could allow the remaining bacteria to multiply, potentially leading to the development of antibiotic-resistant strains. Resistant bacteria pose a more significant threat, making it challenging to treat infections effectively.

Avoiding prolonged illness

Incomplete antibiotic courses may result in a longer recovery period. If bacteria develop resistance due to premature cessation of treatment, it can extend the duration of illness, necessitating additional medications and potentially leading to more severe health consequences.

Preventing overuse

Overusing antibiotics can contribute to antibiotic resistance, especially when not treated appropriately. For instance, taking antibiotics for a viral infection instead of a bacterial one can lead to unintended consequences. It is essential to avoid self-prescribing or using leftover antibiotics, as they may not be the right treatment for the specific illness.

Always consult your healthcare provider for personalized guidance and adhere to their prescribed treatment plan.

What are the signs that Amoxicillin is working?

Understanding the timeline of amoxicillin’s effectiveness and recognizing signs of improvement is essential for patients undergoing treatment. Here are key indicators that amoxicillin is working:

Gradual symptom relief

Amoxicillin does not provide immediate relief from infection symptoms. In most individuals, noticeable improvements typically occur within 72 hours of starting the medication. However, some people may experience positive changes within 24 to 48 hours.

Onset of improvement

Amoxicillin actively combats the infection shortly after initiation, and patients often begin to feel better around 2 to 3 days. It’s important to acknowledge that the medication may take a little time to affect the infection fully.

Consistent medication adherence

Even if symptoms improve before the prescribed course is completed, it is vital to continue taking amoxicillin for the full duration recommended by your healthcare provider. Completing the entire course ensures the thorough eradication of bacteria, reducing the risk of recurrence and antibiotic resistance.

By recognizing these signs and following the prescribed treatment plan, patients can actively contribute to their recovery process and optimize the effectiveness of amoxicillin in addressing the infection. Always consult your healthcare provider for personalized guidance and address any concerns about your treatment.

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Allergies and Precautions

Warning signs of allergic reactions

Recognizing a true allergic reaction is crucial, and warning signs include the sudden onset of a rash within two hours of the first dose, breathing or swallowing difficulties, or developing very itchy hives.

Penicillin allergy and immune sensitivity

Penicillin allergy arises when the immune system becomes hypersensitive to the drug, mistakenly identifying it as harmful. Sensitivity to penicillin occurs after exposure to the medication at least once.

Monitoring symptoms and seeking medical attention:

If symptoms do not improve within a few days or worsen, it is important to consult your doctor promptly for further evaluation.

Serious allergic reaction (Anaphylaxis):

Amoxicillin may cause a serious allergic reaction known as anaphylaxis. Symptoms include skin rash, itching, shortness of breath, difficulty breathing or swallowing, and swelling of hands, face, mouth, or throat. Seek immediate medical attention if any of these signs occur.

Diarrhea caution

Amoxicillin may lead to diarrhea; sometimes, it can be severe, occurring every two months or more after discontinuation. Consult your doctor before using any medication to treat diarrhea, as certain medicines may worsen or prolong the condition.

Impact on medical tests

Inform the doctor conducting medical tests that you or your child are taking amoxicillin, as the medication may affect the results of some tests.

Effect on birth control pills

Amoxicillin may impact the effectiveness of birth control pills. Use an additional form of contraception, such as a condom, diaphragm, or contraceptive foam or jelly, to prevent pregnancy.

Caution with other medications

Do not take other medicines without discussing them with your doctor, including prescription or over-the-counter (OTC) medications and herbal or vitamin supplements. This precaution ensures a comprehensive understanding of potential interactions and side effects.

Other FAQs about Amoxicillin for uti

Can I stop taking Amoxicillin once I feel better?

As a rule of thumb, healthcare professionals and health authorities recommend completing the full prescribed course of antibiotics, even if symptoms improve before completion. This practice aims to prevent the recurrence of infection and mitigate the risk of developing antibiotic resistance.

How many 500mg amoxicillin doses should I take for a UTI?

250 mg orally every 8 hours or 500 mg every 12 hours is recommended for mild to moderate infection. However, for severe infection, 500 mg orally every 8 hours or 875 mg every 12 hours is taken. 

How long does it take for a UTI to spread to the kidneys?

Lower urinary tract infections can progress to kidney infections within a few hours or days. If a kidney infection is suspected, healthcare providers may conduct urine tests and, in some cases, order imaging studies such as a CT scan for further evaluation.

Is it safe to take amoxicillin during pregnancy?

Certain antibiotics are generally considered safe during pregnancy, including penicillins such as amoxicillin (Amoxil, Larotid) and ampicillin, as well as cephalosporins like cefaclor and cephalexin (Keflex).

How can I get Amoxicillin for a UTI without going to the doctor?

You can obtain antibiotics for a UTI through telehealth appointments, eliminating the need for an in-person doctor visit at an online clinic like Your Doctors Online.

Your Doctors Online uses high-quality and trustworthy sources to ensure content accuracy and reliability. We rely on peer-reviewed studies, academic research institutions and medical associations to provide up-to-date and evidence-based information to the users.

  • Ronald AR, Jagdis FA, Harding GK, Hoban SA, Miur PL, Gurwith MJ. Amoxicillin therapy of acute urinary infections in adults. Antimicrob Agents Chemother. 1977 May;11(5):780-4. doi: 10.1128/AAC.11.5.780. PMID: 327919; PMCID: PMC352074.
  • Bailey RR, Abbott GD. Treatment of urinary-tract infection with a single dose of amoxycillin. Nephron. 1977;18(6):316-20. doi: 10.1159/000180849. PMID: 876437.
  • Rubin, Robert H., Leslie ST Fang, Stephen R. Jones, Robert S. Munford, J. M. Slepack, Patricia A. Varga, Linda Onheiber, Catherine L. Hall, and Nina E. Tolkoff-Rubin. “Single-dose amoxicillin therapy for urinary tract infection: multicenter trial using antibody-coated bacteria localization technique.” Jama 244, no. 6 (1980): 561-564.

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