Fluconazole is a member of the triazole family, one of the most widely used antifungal agents. Its common name is Diflucan. Fluconazole was patented in 1981, and commercial usage was started in 1988. It is listed in the World Health Organization’s List of Essential Medicines. Fluconazole is available as a generic medication. In 2020, Fluconazole was one of the most prescribed drugs, with more than three million prescriptions.
It is an antifungal drug that works by slowing the growth of fungi which is a reason for infection. Use of Fluconazole for the treatment of both systemic and superficial fungal infections in a variety of tissues. This drug is an azole antifungal in the same drug family as ketoconazole and itraconazole. Fluconazole has many advantages over other antifungal drugs, including the option of oral administration. The side effect profile of this drug is minimal. It has been an efficacious treatment for vaginal yeast infections in one single dose.
This article will focus on Fluconazole uses its side effects, and all precautions you should take.
How to take Fluconazole?
Do not take it often, and do not take it for longer. Doing so may increase the possibility of side effects. Read and follow the instructions carefully that come with a patient information leaflet.
If it helps improve the condition after the first few doses of this drug, use this medicine for complete treatment. If you stop using the drugs too soon, your infection may not clear. You can take this medicine with or without food. Shake the oral liquid well before use every time. If you are taking the liquid composition of this medicine, then measure with a measuring spoon, medicine cup or oral syringe. The household teaspoon may not hold the right amount of liquid. Take this drug by mouth with or without food once a day.
The fluconazole dosage depends on your medical condition and response to treatment. For children, the dosing is done according to weight. Generally, in children, the dose should not be more than 600 milligrams in a day unless directed by the doctor. Fluconazole works best when the amount of medicine in your body is maintained constantly.
The course of medication should be complete, even if symptoms disappear after a few days. Leaving the medicine too early may cause the fungus to grow, which may result in the infection’s return.
Most adults and children can take Fluconazole. It is also a prescription medicine for babies.
Fluconazole is not suitable for people having the following issues:-
- Heart disease, including heart rhythm problems (arrhythmia)
- Kidney or liver issues
- Allergic reaction to Fluconazole or any other drugs in the past
- Had a blood test that showed abnormal levels of potassium, calcium, or magnesium
- An inherited blood disorder called acute porphyria
Capsules form of Fluconazole are either 50mg, 150mg, or 200mg. Swallow the whole tablets with water. The liquid form usually comes in two different forms:
- 50mg/5ml. 50mg fluconazole in a 5ml spoonful
- 200mg/5ml. 200mg fluconazole in a 5ml spoonful
Dosage for capsules or liquid
Following are the usual doses for adults:-
- Weak immune system: (a low white blood cell count). Take 50mg to 400mg a day until your white blood cell count improves.
- Candida infections: Use 200mg to 800mg a day for several weeks.
- Oral (mouth) thrush: Take 50mg daily for 7 to 14 days.
- Vaginal thrush or balanitis: Use 150mg as a single dose.
- Vaginal thrush that keeps coming back: Take 150mg once every 72 hours for the first three doses, then take 150mg once weekly for six months.
- Cryptococcal meningitis: Take 200mg to 800mg a day for several weeks.
- To stop cryptococcal meningitis from returning: Use 200mg daily for the term.
Note: If you take Fluconazole once every 72 hours, use a calendar and mark the days you need to take it.
How does Fluconazole work?
Fluconazole is an antifungal medication. It works by slowing down the growth of the fungus that’s causing your infection and by inhibiting an enzyme in fungi called lanosterol 14-α-demethylase, which can convert lanosterol (fat to ergosterol). It interferes with the formation of the fungal cell membrane.
Diseases you can treat with Fluconazole
Following are the treatment which these medicines can do:-
- Effective against Cryptococcus neoformans, Candida albicans, C. glabrata, C. parapsilosis, C. tropicalis, and several other Candida species.
- A single oral dose is usually sufficient to treat vaginal candidiasis.
- Fluconazole dose for skin infection can treat certain fungal or yeast infections.
- To treat vaginal candidiasis.
- Effective for other Candida infections such as urinary tract infections, esophagus mouth, peritonitis, and systemic infections.
- To reduce the chances of candidiasis in people receiving chemotherapy, radiotherapy, or undergoing bone marrow transplantation.
- To treat Cryptococcal meningitis in AIDS patients.
Have you caught one of the above Fungal infections? Consult one of our doctors online now for diagnosis and treatment.
How long does it take for Fluconazole to work?
It depends on the fungal condition. If you are suffering from vaginal yeast infection, you may only need one dose of Fluconazole and may see your symptoms start to improve within 24 hours.
For some other infections (like oral thrush), it may take several days before you start to feel better. For more severe conditions, like infections of the blood or liver, it could take longer.
Even if you start feeling better, you should continue taking Fluconazole until your course completes. Stopping Fluconazole too soon can prevent your infection from being fully treated. An incomplete course can cause symptoms of a disease to return.
Usually, a prescription as a single dose for mild, uncomplicated infections will improve symptoms within one to three days.
If a single dose does not relieve symptoms completely or the infection is severe, Fluconazole can, as three consecutive doses three days apart can, help. This practice may improve symptoms within one to two weeks.
If symptoms continue despite suitable treatment, Fluconazole may be recommended for everyday use for ten to fourteen days and even once per week for six months.
In case of an emergency or overdose
If you have taken too many doses accidentally, you could have deadly drug levels in your body.
Symptoms of an overdose of this drug include:-
- Abnormal heart rhythm
- Blue tint to your skin
- Decreased breathing
Acute toxicity of Fluconazole can present with peripheral nervous system involvement. In addition, the patient developed polyneuropathy, a confusional state, acute kidney injury, and thrombotic thrombocytopenic purpura. Reports exist of fluconazole overdose accompanied by hallucinations and paranoid behaviour. If there is an overdose, symptomatic treatment with supportive measures and gastric lavage should be instituted. As Fluconazole excretes in urine, a 3-hour hemodialysis session decreases plasma levels by approximately 50%.
Get help immediately by consulting one of our doctors online if any overdose symptoms occur.
What should you do if you forget a dose?
If you need to remember to take a dose:
- Please take it as soon as you remember unless it’s time for your next dose.
- In this case, pass the missed dose and take your next one as standard.
- Take a double amount to cater for a missed dose. If you forget doses often, then set the alarm to remind you.
Precautions you should follow.
Before taking Fluconazole
- Acquaint your doctor if you are allergic to Fluconazole, other antifungal medications such as posaconazole (Noxafil), voriconazole (Vfend), itraconazole (Sporanox), ketoconazole (Nizoral) or any of the ingredients in fluconazole tablets.
- Take advice from your doctor if you are taking astemizole (Hismanal) (not available in the U.S.), cisapride (Propulsid) (not available in the U.S.), quinidine (Quinidex), erythromycin (E.E.S., E-Mycin, Erythrocin); pimozide (Orap) or terfenadine (Seldane). Your doctor will advise you not to take Fluconazole if you take any of these medications.
- Explain to your doctor what prescription and nonprescription vitamins, medications, nutritional supplements, and herbal products you plan to take.
- Communicate with your doctor if you have or have ever had cancer, an irregular heartbeat, or acquired immunodeficiency syndrome (AIDS)
- Inform your doctor if you are pregnant, especially if you plan to become pregnant, are in the first three months of your pregnancy, or are breastfeeding. Your doctor can advise you to use birth control to prevent pregnancy while using medicines.
- If you have dental surgery or surgery, inform your dentist or doctor that you are using Fluconazole.
- As Fluconazole may make you dizzy or cause seizures, do not operate machinery or drive a car until you know how this drug can affect you.
Side effects of Fluconazole
Immune-compromised or HIV/AIDS patients are likely to have fluconazole side effects. Fluconazole’s side effects, such as nausea, headache, and stomach pain, can start quickly if given an injection. But when taking Fluconazole by mouth, minor side effects could occur within an hour or two.
Common side effects
- Headache. It is the most common side effect in people receiving a single large dose.
- Nausea. It is the most common side effect in people taking multiple smaller doses.
- Abdominal pain. This is a common side effect of Fluconazole, which is more likely with the administration of the drug in a single large dose. In clinical trials, about 6% of people getting one large dose complained of stomach pain.
Other common side effects may include
- Acid indigestion
- Changes in how things taste
- Skin rash. This is an uncommon side effect of Fluconazole and mainly happens in people taking Fluconazole over several days. A skin rash may not be a medical emergency, but it could be an initial symptom of a severe and sometimes even life-threatening skin reaction to the drug.
Serious side effects of Fluconazole
The most severe side effects of Fluconazole include the following:
- Liver problems
- Decreased white blood cell or platelet counts
- Heart rhythm changes
- Decreased adrenal gland function
- Severe allergic or skin reactions
Storage and disposal of Fluconazole
For storage and disposal purposes, always follow under mentioned points:
- Keep this medication in the container in which it came.
- Do not keep outdated medicine or medicine that is no longer needed.
- Keep out of reach of children. It is essential to keep all medication out of reach of children. Many containers are not child-resistant, and they can open easily. Therefore always lock safety caps and keep the medicine in a safe location.
- Store it at room temperature.
- Keep away from excess heat and moisture.
- Dispose of unused liquid medication after 14 days.
- Unneeded medications should be disposed of in unique ways to ensure that children, pets, and others cannot consume them.
- Never flush this medication down the toilet.
- The most appropriate way to dispose of your medication is through a medicine take-back program.
Consult our doctors to learn about take-back programs in your community.
How to reduce its side effects?
Most people will experience mild or no side effects while taking Fluconazole. If they have, then they’re usually manageable. Here are some practical ways to minimize and reduce the possibility:
Follow the instructions
Follow all instructions given by the prescriber or written on the prescription label while taking Fluconazole. Only take what is instructed.
Rest assured, the prescriber has a complete medical history.
Medical status may affect whether Fluconazole causes problems, so make sure the prescriber is well aware of these conditions mainly:
- Heart rhythm problems
- Low potassium or other electrolyte imbalances
- Liver problems
- Heart disease
- Kidney problems
- Pregnancy or pregnancy plans
- Breastfeeding or breastfeeding plans
Make sure the prescriber is well aware of all medications.
The prescriber needs to know the prescription drugs, vitamins, over-the-counter medications, or dietary supplements being taken.
Take Fluconazole with food.
Use Fluconazole pills or fluconazole oral solutions with or without food. If nausea is a problem, take each dose with a snack or meal.
Avoid pain relievers
Fluconazole may increase side effects like stomach pain caused by NSAIDs like naproxen and ibuprofen. This is not dangerous, but use acetaminophen for pain or fever instead.
How to treat side effects of Fluconazole
Following are the ways to manage side effects:-
- Fluconazole and alcohol have an interaction. Don’t t drink too much alcohol.
- Take an over-the-counter pain reliever like acetaminophen.
- Drink plenty of fluids and rest in a cool, dark, quiet room.
Fluconazole can cause dangerous liver problems, so contact a doctor if any symptoms of liver dysfunction are noticed, such as:
- Foul-smelling or dark urine
- Pale/clay-coloured stools
- Loss of appetite
- Whites of the eyes
- Yellowing of the skin
- Try to rest and relax.
- Eat and drink slowly
- and have smaller and more frequent meals.
- Put a heating pad or covered hot water bottle on your tummy
- If you are in severe pain, talk to our doctor
- Drink lots of fluids to avoid dehydration.
- Do not take other medicines to treat diarrhea without speaking to a pharmacist or doctor.
Feeling or being sick (nausea or vomiting)
- Use simple meals and do not eat rich or spicy food.
- Have small sips of water to avoid dehydration.
Factors that increase the risk of a reaction
While rare, severe, life-threatening allergic or skin reactions may occur. Patients taking Fluconazole should be alert to signs of an allergic reaction, like difficulty breathing, hives, or tongue, face, lips or throat swelling.
Patients should also be alert to symptoms of a severe skin reaction such as fever, burning eyes, sore throat, red or purple rash, or blistering or peeling skin. Emergency medical attention is required for patients experiencing an allergic or skin reaction.
Discuss your risk factors for a reaction with one of our doctors online.
How long do side effects last?
Fluconazole is a short-term, time-limited treatment. It can be given as single large or multiple daily doses for one to three weeks. Most people can expect side effects to resolve when treatment stops. However, it takes some time for the body to clear a dose. Healthy people clear Fluconazole in about five days, but it may take two to three weeks in people with kidney disease. Severe but rare adverse effects like lowered white blood cell counts or adrenal insufficiency may take several weeks to recover.
Fluconazole is an antifungal medication. It’s an option for many situations, such as yeast infection. But many fluconazole interactions can be harmful if left unchecked.
Fluconazole is known to interact with many other medications. Some of which you may be taking. Sharing the details of medicines with your doctor is helpful before you start your new prescription. This helps them prevent and check for any possible medication interactions.
It is a blood-thinning medication. It treats and prevents blood clots. This helps stop certain complications for people with atrial fibrillation and strokes. After taking warfarin, it gets broken down by two specific enzymes. Fluconazole prevents these enzymes from working efficiently. So if you take warfarin and Fluconazole simultaneously, the INR can go up. It leads to blood thinning which can be dangerous if not managed.
Your doctor may want to lower your warfarin dose if you are to take Fluconazole simultaneously. You will be required to investigate INR often because an elevated INR can raise your risk of bleeding.
It is a drug that is used in the treatment of abnormal heart rhythms. Fluconazole can also lead to changes in heart rhythm, albeit unintentionally. There’s an elevated risk of developing irregular heart rhythms when taken together. Fluconazole also makes amiodarone stick around the body for longer, prolonging its efficacy.
Your doctor may want to track your heart rhythm more often while taking both medications. Additionally, they may want to ensure that your body’s potassium and magnesium levels are normal. This can help prevent heart problems.
Clopidogrel is a frequently used antiplatelet medication. It’s a medicine to lower the risk of heart attack and stroke prescribed in certain patients.
However, clopidogrel does not start to work right away. It works only after enzymatic activation. Fluconazole can stop this enzyme from working, making it ineffective and can worsen and increase the risk of cardiac complications.
If you are on clopidogrel, it may be a good idea to check in with our doctors to see if any dose adjustments or other changes are necessary.
It is a medicine to help prevent seizures in people with epilepsy. Normally, phenytoin gets excreted from your body by an enzyme. Fluconazole can hinder this. It may lead to serious phenytoin side effects because it stays in your body longer. It can contribute to cardiac side effects, like hypotension or heart rhythm abnormalities. Brain-related side effects, like slurred speech, drowsiness, and dizziness, can also occur.
If you take phenytoin, your doctor may want to track your phenytoin levels more often while on Fluconazole. Your healthcare provider may also lower your dose of phenytoin.
It is a typical high-cholesterol medication that benefits several health conditions, like heart disease and diabetes, but interactions are a frequent concern.
Atorvastatin gets removed from the body by a specific enzyme, but Fluconazole may hinder it. It can result in increased atorvastatin levels in the body.
Elevated atorvastatin levels can lead to more side effects. These can include rhabdomyolysis or muscle pain, where your muscles break down and release harmful by-products.
It is an antidepressant drug used in depression treatment. It raises the amount of serotonin in your brain to help improve mood.
However, increased serotonin can be dangerous. Elevated serotonin could lead to serotonin syndrome, a severe health condition. It doesn’t typically cause serotonin syndrome on its own, but the risk is higher while on Fluconazole. This is because Fluconazole slows down the two enzymes that usually break down citalopram.
Serotonin syndrome’s severity varies. Mild symptoms include shaky hands, sweating, and an increased heart rate. But in rarer cases, more severe symptoms can occur.
The following symptoms are the recommendation for Emergent medical care :
- Rapid eye movements
- An inability to open your mouth (lockjaw)
- Uncontrolled movement of arms and legs
- Difficulty in rising from lying or sitting position
Additionally, some antidepressants can affect your heart and raise the risk of abnormal rhythms. As with amiodarone, taking citalopram and Fluconazole can increase the risk of heart rhythm problems. This risk is higher for people who have preexisting heart problems.
If you’re taking both citalopram and Fluconazole together, citalopram’s labelling recommends limiting the dose to 20 mg once daily while taking Fluconazole.
Our bodies have many enzymes (proteins) that naturally affect how certain medications work. Some enzymes “activate” medicines so they can start working, whereas others break drugs down so they can exit your body. Fluconazole has many interactions because it can stop some enzymes from working as they should.
Fluconazole’s behaviour can make some medications stick around in your body for longer than they need to. This increases the odds of side effects. On the other hand, blocking these enzymes can make other medications less effective. So, if you took any drugs or supplements and were just given a prescription for Fluconazole, these interactions are essential to know about.
Keep in mind: This isn’t an exhaustive list of medications that Fluconazole can interact with.
How to get a fluconazole prescription?
Worried that you may be having a fungal infection. Fluconazole may be the right choice to treat it depending on the condition of the disease, age of the patient, weight, and general medical condition. Some formulations may be available over the counter, but most require a prescription.
FAQs about Fluconazole Answered by Your Doctors Online Team
Fluconazole is in a class of antifungals known as triazoles, which works by slowing the growth of fungi that cause infection.
It is not a steroid, as Fluconazole is used to prevent and treat various fungal and yeast infections.
Healthy people clear Fluconazole in about five days, but it may take two to three weeks in people with kidney disease. Severe but rare adverse effects like lowered white blood cell counts or adrenal insufficiency may take several weeks to recover from
If symptoms continue even after treatment, Fluconazole may be prescribed daily for ten to fourteen days.
Most women only need one dose of Fluconazole for vaginal yeast infections. However, more severe conditions may require a second dose (three days after the first dose).