How to take Doxycycline for sinus infection?

doxycycline for sinus infection
Medically reviewed by Dr. Mehvish Khan

Key Takeaways

  • Sinus infection, also called sinusitis, is a bacterial infection that needs medical consultation and a dosage regimen for complete treatment. 
  • Healthcare providers prescribe doxycycline for sinus infections, which helps relieve the symptoms and treats infection. 
  • Doxycycline works by stopping the growth of bacteria and making unfavorable conditions for bacteria to survive in the body, eventually leading to the death of a bacteria. 
  • Consult your healthcare provider for the correct diagnosis and dosage regimen per your medical needs. 


Sinusitis is an infection of the sinus cavity of the nasal cavity caused by bacteria. 

Doxycycline belongs to the bacteriostatic class that kills bacteria by creating unfavorable conditions for bacteria to survive. This medication is not an OTC medication and can only be dispensed with a prescription from a healthcare provider. The typical starting dose of doxycycline for adults is 100mg twice daily for 7 to 14 days. It’s recommended to be taken with water and after meals to avoid GIT disturbances. Consultation with your healthcare provider is beneficial for accurate diagnosis and dosage regimen. 

How does Doxycycline work for a sinus infection?

Doxycycline works for sinus infection by inhibiting the growth of bacteria. It not only inhibits the growth of bacteria but also inhibits the growth of essential proteins made by bacteria for survival. It targets the growth and reproduction of the bacteria, leading to bacterial cell death. Doxycycline belongs to the bacteriolytic (killing bacteria) class of antibiotics that kills bacteria by stopping their growth and reproduction. 

You can now get the doxycycline prescription from our healthcare provider within minutes!

How to take Doxycycline for sinus infection?

Four major factors must be considered before taking for a sinus infection. Antibiotics are not over-the-counter medications and should only be taken as prescribed by your healthcare provider. The typical dose of prescribed doxycycline for adults to be taken for sinus infection is 100mg twice daily for 7 to 14 days. It is mainly recommended to be taken with water and after meals to avoid GIT disturbances of abdominal discomfort. Finish the entire course of medication, even if symptoms improve, to ensure the infection is completely treated.

Avoid taking doxycycline with dairy products, calcium supplements, or antacids containing aluminum, calcium, or magnesium, as these can interfere with the absorption of the medication.

What are the alternative medications for sinus infection? 

Certain other medications should be taken as an alternative for the sinus infection. It can only be decided and determined by your doctor and pharmacist. You will be prescribed an alternative medication if you are allergic to doxycycline. 

Some of the best alternative options for the following: 

It’s beneficial to get the antibiotic prescription only if your healthcare provider prescribes it.    

Get doxycycline or alternative medication prescription after consultation with providers of your doctors online.

What side effects should you expect with Doxycycline?

Here are some of the most common and severe side effects of doxycycline: 

Common side effects:

  • Nausea
  • Vomiting
  • Diarrhea
  • Stomach upset or pain
  • Loss of appetite
  • Sensitivity to sunlight (increased risk of sunburn)
  • Headache
  • Dizziness
  • Yeast infections in women (vaginal itching or discharge)
  • Skin rash or itching

Severe side effects:

The following are less common but potentially severe side effects that require immediate medical attention: 

  • Severe skin reactions (e.g., blistering, peeling, or a widespread rash)
  • Difficulty swallowing or breathing
  • Swelling of the face, lips, throat, or tongue
  • Severe headache or blurred vision
  • Chest pain or irregular heartbeat
  • Dark urine or yellowing of the eyes or skin (jaundice)
  • Severe stomach or abdominal pain
  • Persistent vomiting or diarrhea
  • Signs of a severe allergic reaction (e.g., hives, itching, or difficulty breathing). 

What are the precautions of taking Doxycycline for a sinus infection?

Some significant precautions that should be observed during sinus infection include taking the antibiotic only when prescribed until the prescribed duration. Doxycycline should be taken with food or water to avoid stomach pain and discomfort. 

Limiting sunlight exposure is also recommended as it can increase sensitivity to sunlight. Inform your healthcare providers about the allergies. 

Talk to a healthcare professional now and get a personalized doxycycline prescription for your sinus infection! 

When should I see a doctor?

Doxycycline is an antibiotic that requires a prescription and a dosage regimen before being dispensed to you. You can get a consultation and prescription for your medical condition from our healthcare providers anywhere around the globe. 

FAQs about Doxycycline for sinus infection

Can I request a Doxycycline prescription from my healthcare provider?

Yes, you can. If you need a Doxycycline prescription, you can request a prescription. Other alternatives can be online prescription request services, where you can get one by requesting in with our mobile app.

Can I use Doxycycline for sinus infections during pregnancy or while breastfeeding?

It is generally not recommended to use Doxycycline while pregnant or breastfeeding due to its penetration properties from the placenta to the developing fetus. It can cause fetal anomalies, including impaired tooth and bone development.

How long does it usually take for Doxycycline to start working for a sinus infection?

It usually takes the first 72 hours to show effectiveness and improvement in the symptoms. Doxycycline treatment can take 5-7 days/week. It’s beneficial to follow the prescribed regimen.

What should I do if my symptoms persist after completing a Doxycycline course?

Consult your healthcare provider before continuing Doxycycline or any other medication to adequately cater to your medical needs. Discuss your medication and medical condition history with your healthcare provider for the correct diagnosis. 

What are the drug Interactions with Doxycycline?

Doxycycline shows interactions with drugs, including antacids having aluminum, calcium, or magnesium, penicillin antibiotics, anticoagulants (warfarin), barbiturates, some seizure medications (phenytoin, carbamazepine), oral contraceptives, Isotretinoin and bismuth subsalicylate.

Your Doctors Online uses high-quality and trustworthy sources to ensure content accuracy and reliability. We rely on peer-reviewed studies, academic research institutions and medical associations to provide up-to-date and evidence-based information to the users.

  • Cunha, Burke A., Carol M. Sibley, and Angela M. Ristuccia. “Doxycycline.” Therapeutic drug monitoring 4.2 (1982): 115.
  • Stalman, W., et al. “The end of antibiotic treatment in adults with acute sinusitis-like complaints in general practice? A placebo-controlled double-blind randomized doxycycline trial.” British journal of general practice 47.425 (1997): 794-799.
  • Axelsson, A., and J-E. Brorson. “Concentration of Antibiotics in Sinus Secretions: Doxycycline and Spiramycin.” Annals of Otology, Rhinology & Laryngology 82.1 (1973): 44-48.
  • Axelsson, Alf, et al. “Treatment of Acute Maxillary Sinusitis: Doxycycline and Spiramycin with and without Irrigation.” Annals of Otology, Rhinology & Laryngology 82.2 (1973): 186-191.

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