How does Clomid work for treating fertility?

Medically reviewed by Dr. Mandy Liedeman


Clomid for pregnancy is a medication commonly used to help women who are having trouble getting pregnant. Clomiphene citrate is marketed under the name Clomid. It is a typical medication used to aid in infertility. It’s like a helper for men and women who struggle with infertility. Here’s how it works: Clomid tells the brain to make more hormones that lead to releasing eggs or sperm. So, it encourages the ovaries to release eggs, giving a better chance for pregnancy. But everyone’s body is different, so doctors must monitor things to ensure they work well. Beyond the science, using Clomid is a big deal emotionally. It’s not just about medicine – it’s about the strong desire to become parents. So, Clomid is not just a pill; it’s a part of many people’s journey toward having a family full of hope and determination.

Does Clomid help fertility? 

Indeed, Clomid is intended to aid in conception and is considered one of the strongest fertility pills. It’s a drug that’s frequently provided to women who experience problems ovulating and becoming pregnant—clomid acts by inducing the brain to release hormones, which triggers the ovaries to release eggs. The likelihood of conception may rise as a result of this increased ovulation.

Clomid triggers a hormonal response by binding to estrogen receptors in the brain, prompting increased follicle-stimulating hormone (FSH) production. FSH stimulates ovarian follicles, promoting the growth and maturation of eggs for potential fertilization.

“Clomid pill serves as a valuable adjunct in addressing infertility, offering a targeted approach to stimulate ovulation and optimize reproductive potential, guided by careful monitoring and personalized care.”  

Says Dr. Richard Honaker

When is Clomid prescribed for fertility?

Clomid for fertility is prescribed when a woman is experiencing difficulties getting pregnant due to irregular or absent ovulation. Here are some common scenarios where Clomid might be recommended:

Irregular ovulation

Clomid and ovulation are closely linked, as Clomid is often prescribed to induce ovulation in women experiencing absent or irregular menstrual cycles. If a woman has irregular menstrual cycles or is not ovulating regularly, Clomid may be prescribed to stimulate ovulation.

Polycystic ovary syndrome (PCOS)

Clomid for women with PCOS serves as a hope for getting pregnant. Women with PCOS often have irregular ovulation, and Clomid can be used to induce ovulation in such cases.

Unexplained infertility

Clomid is a first-line treatment for infertility that may be used when other options have been exhausted and the cause of the infertility is unclear.

Luteal phase defect

If an issue with the luteal stage (the second half of the menstrual cycle) affects fertility, Clomid may be administered.

Male factor infertility

Male factor infertility involves issues with sperm production, quality, or delivery. Clomid, typically used to stimulate ovulation in women, may also be prescribed off-label for men with low testosterone levels to enhance sperm production by stimulating the pituitary gland, but its efficacy in treating male infertility remains uncertain and requires further research and clinical evaluation.

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How do I get pregnant on Clomid?

If you’ve been prescribed Clomid to help with fertility and want to maximize your chances of getting pregnant, here are some general tips to follow:

Follow your doctor’s instructions

Take Clomid exactly as your healthcare provider prescribes. Follow the recommended dosage and timing instructions.

Regular monitoring

Your doctor may recommend regular monitoring through blood tests or ultrasounds to track your ovulation and adjust the Clomid dosage if needed.

Timing intercourse

Be aware of your fertile window. Ovulation typically occurs about 5-10 days after finishing a course of Clomid—plan to have intercourse during this time to increase the chances of conception.

Use ovulation prediction kits (OPKs)

OPKs can help you predict when ovulation will occur. Start using them a few days after finishing Clomid, and when the test indicates a surge in luteinizing hormone (LH), it’s a sign that ovulation is approaching.

Regular intercourse

Aim for regular intercourse throughout your menstrual cycle, but especially during the fertile window. This increases the likelihood of sperm meeting the egg when ovulation occurs.

Maintain a healthy lifestyle 

Maintain a healthy lifestyle using a balanced diet and regularly exercising. These circumstances may positively impact fertility.

Minimize stress

Stress can hurt fertility. Seek methods to reduce stress by engaging in enjoyable activities, exercise, or relaxation techniques.

Patience and persistence

Getting pregnant may take time, even with fertility treatments. Be patient and share openly with your doctor about your progress and any concerns.

Clomid has been effective in inducing ovulation. Consult now!

Clomiphene citrate for ovulation induction

For women without a menstrual cycle, Clomiphene combined with the drug Provera may help start ovulation and menstruation:

  • Starting treatment involves taking Provera orally for five to seven days.
  • When Provera is finished, a menstrual cycle should start two to three days later.
  • The first day of menstrual flow is the third, fourth, or fifth day after clomiphene treatment.
  • A 50 mg clomiphene citrate tablet is taken orally for five days.
  • Ultrasonography monitoring is done on days 11 or 12 of the menstrual cycle to determine if an ovarian follicle or follicles have developed. Patients are also instructed to use an ovulation prediction kit to check their urine for a spike in luteinizing hormone (LH), which indicates that eggs have matured and ovulation is about to occur. The discharge of the mature egg(s) from the follicle(s) during ovulation can be caused by injecting the medicine hCG (Ovidrel) if no LH surge is detected.
  • Insemination through natural means occurs at the same time as ovulation.
  • Progesterone is administered as a vaginal tablet or gel if hCG injections are used to induce ovulation. The progesterone hormone helps to prepare the uterine lining, or endometrial lining, for the fertilized egg.
  • Patients are asked to do a home pregnancy (urine) test two weeks post-ovulation. A blood test will confirm results if the test is positive.

A second round of provera will be recommended, and the clomiphene dosage will be increased until ovulation happens if ovulation is not achieved during this first round of clomiphene. If there are still cysts on the ovarian follicles, it can be possible to start another clomiphene cycle right away. If not, it might be recommended to wait a cycle before beginning treatment again.

This course of treatment will be stopped if ovulation induction is not possible, even with a larger dose of clomiphene. A different fertility medication, such as letrozole or gonadotropins, may be tried again.

What is the dosage of Clomid for women’s infertility treatment?

The typical starting dosage of fertility pill Clomid (clomiphene citrate) for infertility treatment is 50 milligrams (mg) per day for five days, beginning on either the third, fourth, or fifth day of the menstrual cycle. The treatment cycle usually repeats for three to six months, depending on the response.

If ovulation does not occur at the initial dosage, the doctor or gynecologist/obstetrician may look into increasing the dosage. The most common dosage adjustments are increments of 50 mg, up to a maximum of 150 mg per day. The goal is to find the lowest effective dosage that induces ovulation.

What are the success rates of Clomid for fertility?

About 70% of anovulatory women (those who are unable to develop an egg each month) will ovulate after receiving clomiphene treatment; conception rates commensurate with the patient’s age should be attained. If there are no other relevant circumstances, women under 35 can achieve pregnancy rates of 20–25% every month. Due to the aspect of deteriorating egg quality, older patients might not reach these rates. We emphasize that success rates are pretty unique and contingent upon several factors. The best course of action is to have a comprehensive conversation with one’s RE physician about the chances of success with this or any treatment strategy.

For those who do not become pregnant with clomiphene therapy, there are other fertility medications available. Other ovulation induction techniques may be suggested if three complete clomiphene cycles fail to produce a pregnancy. Gonadotropins and intrauterine insemination might be advised for older adults. The best course of action for younger individuals, for whom the risk of multiple gestations with gonadotropins and IUI may be too great, maybe to proceed with in vitro fertilization.

Want to know the best infertility treatment? Consult now!

When should I see a doctor?

If you’re having difficulty getting pregnant and are considering fertility treatments, including medications like Clomid, it’s advisable to see a doctor sooner rather than later. Seeking medical advice is recommended if your age is less than 35 and you have been actively trying to conceive for a year but have not succeeded. If your menstrual cycles are irregular, unpredictable, or absent, this may indicate an issue with ovulation. Also, if you have experienced multiple miscarriages, it’s essential to consult with a healthcare provider to investigate potential underlying causes.

FAQs about Clomid for fertility

How do you take Clomid 50 Mg Tablet Fertility Stimulating Preparations?

Clomid (clomiphene citrate) 50 mg tablets are typically taken orally once a day for five days, starting on the second day of the menstrual cycle, for women seeking fertility treatment. It’s crucial to follow the prescribed dosage and timing precisely, as directed by a healthcare professional, to optimize its effectiveness in stimulating ovulation.

What are the risks of taking Clomid when you already ovulate?

People who are already ovulating and are administered Clomid may go through a controlled hyperstimulation of the ovaries, known as superovulation. An individual will release many eggs each month during this procedure, perhaps increasing the likelihood of becoming pregnant.

Can Clomid help me get pregnant fast?

Almost 80% of women who use Clomid experience the discharge of mature eggs as a result of its excellent ovulation-stimulating effects. Only roughly 10% to 13% of individuals will become pregnant each cycle. Clomid is, therefore, not a panacea for infertility.

How many rounds of Clomid does it normally take to get pregnant?

Four out of ten patients on Clomid treatment will conceive, and seven individuals will ovulate. The first three months of treatment are when most women ovulate. Other ovulation induction techniques should be considered if you have not conceived despite ovulating for six cycles.

How quickly does Clomid work?

Some women may experience ovulation within a week to 10 days after completing a course of Clomid, though it can vary based on individual factors and dosage adjustments. 

How effective is Clomid?

Women taking Clomid for ovulation have an 80% chance of ovulating within the first three months, with success rates varying based on age. Notably, around 40% of those who ovulate may conceive.

Your Doctors Online uses high-quality and trustworthy sources to ensure content accuracy and reliability. We rely on peer-reviewed studies, academic research institutions and medical associations to provide up-to-date and evidence-based information to the users.

  • Kase, Nathan, Adnan Mroueh, and Lowell E. Olson. “Clomid therapy for anovulatory infertility.” American Journal of Obstetrics and Gynecology 98.8 (1967): 1037-1042.
  • Kistner, R. W. “Induction of ovulation with clomiphene citrate (Clomid).” South African Medical Journal 5.2 (1967): 25-35.
  • Quagliarello, John, and Gerson Weiss. “Clomiphene citrate in the management of infertility associated with shortened luteal phases.” Fertility and Sterility 31.4 (1979): 373-377.
  • Konstantinovsky, Michelle. “How Clomid Can Treat Low Testosterone and Infertility.”

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