Sertraline for Premature Ejaculation: How Does it Help?

Sertraline for premature ejaculation
Medically reviewed by Dr. Mavra Farrukh

Key Takeaways

  • Sertraline, known for treating depression, effectively increases stamina in managing premature ejaculation, providing a potential solution.
  • Whether taken daily or strategically timed, sertraline proves effective in prolonging ejaculation time, ensuring convenience.
  • Sertraline outperforms dapoxetine in critical aspects. Consulting a healthcare professional is essential for managing side effects and ensuring safe treatment.


Have you ever felt the frustration of an eagerly anticipated moment falling short of expectations? Much like the abrupt ending of a captivating movie, premature ejaculation (PE) can leave you disappointed in the bedroom. This common condition, experienced by up to 39 percent of men, extends beyond the scope of intimate encounters, potentially leading to feelings of depression and anxiety if left untreated. Sertraline is a medication primarily known for its role in treating depression. Surprisingly, recent research suggests that sertraline may also hold promise in addressing premature ejaculation. In this article, we will cover the effect of sertraline, its mechanism of action, and effectiveness in extending stamina. Additionally, we explore alternative treatment options, offering a comprehensive guide for those seeking solutions to the challenges posed by premature ejaculation.

Get an online consultation with one of our qualified professionals to get a Sertraline prescription

How effective is sertraline for premature ejaculation?

While not exclusively designed for premature ejaculation treatment, selective serotonin reuptake inhibitors (SSRIs), including sertraline, emerged as an effective solution. A 2019 study hails SSRIs as the gold standard for PE treatment, establishing their credibility. Administered twice daily or strategically timed 6-8 hours before sexual activity, sertraline showcased its ability to extend ejaculation time. This dual-pronged approach not only increased the duration of sexual encounters but also contributed to heightened satisfaction for both individuals with PE and their partners. In essence, the scientific landscape leans towards the effectiveness of sertraline, positioning it as a potential game-changer in the pursuit of managing premature ejaculation.

How long does it take for sertraline to work for premature ejaculation?

Sertraline, also known as Zoloft or sertraline hydrochloride, operates indirectly to delay ejaculation, presenting a multifaceted approach to addressing this common concern. At the core of sertraline’s effectiveness lies its role as a selective serotonin reuptake inhibitor (SSRI). By reducing serotonin reuptake in the brain, sertraline enhances mood regulation, relieving the extremes associated with certain mood disorders.

Translating these neurological benefits to sexual function, various studies prove sertraline’s ability to extend stamina, quantified as intravaginal ejaculation latency time (IELT). A clinical trial involving 46 men with premature ejaculation demonstrated significant improvements with a gradual increase in sertraline dosage. Notably, a 25-milligram dose elevated the average ejaculatory interval from one minute to 7.6 minutes, reaching 16.4 minutes at a 100-milligram dose.

Despite the impressive results, side effects were limited, with less than 10 percent reporting issues such as dyspepsia, anxiety, drowsiness, anorexia, erectile dysfunction (ED), and reduced libido. Moreover, studies, including a 1999 publication, emphasize the adaptability of sertraline, showing efficacy even when used on an as-needed basis. After just four weeks, a noticeable improvement in premature ejaculation was observed. While on-demand sertraline demonstrated positive results with fewer side effects, daily usage exhibited superior outcomes, suggesting flexibility in treatment options.

In essence, the timeline for sertraline’s impact on premature ejaculation unfolds over weeks, mirroring its efficacy in other conditions. Whether taken daily or as needed, sertraline offers a viable solution, improving sexual satisfaction and enhancing control over ejaculation.

Get an online consultation with one of our qualified professionals to get a Sertraline prescription

When to take sertraline for premature ejaculation?

Navigating the timing of sertraline intake is crucial for optimizing its impact on premature ejaculation. In a comparative study, individuals were divided into two groups: one taking sertraline twice daily and the other ingesting it four hours before sexual activity. Encouragingly, both approaches demonstrated efficacy in prolonging ejaculation time. Whether incorporated into daily routines or strategically timed before intercourse, sertraline showcased its potential to enhance sexual performance and satisfaction.

Is sertraline or dapoxetine better for premature ejaculation?

For premature ejaculation management, the choice between sertraline and dapoxetine requires thoughtful consideration by a healthcare professional. A comparative analysis revealed that while both medications exhibited positive outcomes, the sertraline group surpassed the dapoxetine group in crucial aspects. The sertraline medication demonstrated superior results in ejaculation latency, ejaculation control, and overall patient satisfaction.

Furthermore, even individuals suffering from severe premature ejaculation witnessed mild-to-moderate improvement in intravaginal ejaculation latency time (IELT) when treated with sertraline. This highlights the efficacy of sertraline as a potent option in the treatment landscape, offering not only extended ejaculation control but also heightened patient satisfaction, especially when compared to dapoxetine.

What are the side effects of sertraline for premature ejaculation treatment?

As sertraline emerges as a potential solution for premature ejaculation, it’s important to know the potential side effects it imposes. While this medication may alleviate premature ejaculation symptoms, it’s not without considerations. For some individuals, sertraline has been associated with a decrease in sex drive and the onset of erectile dysfunction.

The mechanism behind this lies in serotonin, a neurotransmitter that, when increased by sertraline, can influence sexual function. Elevated serotonin levels may contribute to lowered sex drive or compromised erection quality. The prevalence of sexual side effects is not precisely defined, but it’s estimated to impact up to 80% of individuals taking selective serotonin reuptake inhibitors (SSRIs), including sertraline.

Common side effects of sertraline encompass changes in sleep patterns, ranging from difficulty falling or staying asleep to excessive tiredness. Additionally, fluctuations in weight, increased sweating, alterations in sex drive and desire, and changes in sexual function or performance may be observed. Nausea, vomiting, and dizziness are also potential considerations.

If you encounter sexual problems or any side effects while using sertraline, open communication with your healthcare provider is essential. Abruptly discontinuing the medication is not advised. Instead, your healthcare provider may recommend a gradual reduction in dosage to mitigate potential additional side effects.

Get an online consultation with one of our qualified professionals to get a Sertraline prescription

Consult a doctor

Premature ejaculation, a common concern that spans across age groups, can impact the intimate experiences of men, regardless of their sexual history or age-related changes. If premature ejaculation becomes a recurrent issue, seeking guidance from a doctor is advised. 

If you’ve initiated sertraline and find it ineffective or experience side effects, reporting these observations to your healthcare provider is crucial. While mild and transient symptoms like nausea and headaches may require patience as your body adjusts to the medication, certain symptoms may indicate serious side effects.

If you notice signs such as difficulty concentrating and weakness, it suggests low sodium levels due to sertraline use. Additionally, symptoms like shivering, fever, diarrhea, and muscle tightness may raise concerns about serotonin syndrome. By communicating any concerns to your doctor, you can avoid the risks of severe side effects. 

Other FAQs about Sertraline

Which deficiency causes premature ejaculation?

Vitamin B12 is a crucial factor in serotonin synthesis, playing a significant role in ejaculation. In one study, individuals with a deficiency in B12 exhibited lower intravaginal ejaculation times (IET) and higher scores on the premature ejaculation diagnostic tool.

Does sertraline make you last longer in bed?

The elevation of serotonin levels influences the timing of ejaculation, as low serotonin levels in the body may lead to quicker ejaculation. As sertraline enhances serotonin levels, there is a potential for prolonging the time before ejaculation. Researchers have explored its efficacy in addressing premature ejaculation.

How long can you stay on sertraline?

Following symptom improvement, it is advised that you continue taking sertraline for several additional months. Discontinuing the medication prematurely may result in a recurrence of depression. Most healthcare professionals advise continuing antidepressant use for six months to a year after the cessation of depressive symptoms.

Your Doctors Online uses high-quality and trustworthy sources to ensure content accuracy and reliability. We rely on peer-reviewed studies, academic research institutions and medical associations to provide up-to-date and evidence-based information to the users.

  • Yi ZM, Chen SD, Tang QY, Tang HL, Zhai SD. Efficacy and safety of sertraline for the treatment of premature ejaculation: Systematic review and meta-analysis. Medicine (Baltimore). 2019 Jun;98(23):e15989. doi: 10.1097/MD.0000000000015989. PMID: 31169738; PMCID: PMC6571276.
  • Siroosbakht S, Rezakhaniha S, Rezakhaniha B. Which of available selective serotonin reuptake inhibitors (SSRIs) is more effective in treatment of premature ejaculation? A randomized clinical trial. Int Braz J Urol. 2019 Nov-Dec;45(6):1209-1215. doi: 10.1590/S1677-5538.IBJU.2019.0121. PMID: 31808410; PMCID: PMC6909853.
  • McMahon CG. Treatment of premature ejaculation with sertraline hydrochloride. Int J Impot Res. 1998 Sep;10(3):181-4; discussion 185. doi: 10.1038/sj.ijir.3900344. PMID: 9788108. (

Get started today

Talk to online doctors now and get medical advice, online prescriptions, and referrals within minutes. On-demand healthcare services at your fingertips.

talk to online doctor 24/7 free

See a doctor now

Continue in Browser