Spironolactone for acne: How to take it

Spironolactone for acne
Medically reviewed by Dr. Mavra Farrukh

Key Takeaways

  • Spironolactone treats hormonal acne by blocking androgens, reducing oil production, and preventing deep cystic lesions on the jawline and chin.
  • Spironolactone for acne requires careful dosage adherence, consideration of individual responses, and understanding the consequences of missed doses or overdoses.
  • Safe and effective acne treatment with Spironolactone requires awareness of potential interactions with potassium supplements and NSAIDs.


Chronic acne, especially hormonal acne, can be difficult to manage. Spironolactone, an anti-androgen, may help those suffering from hormonal acne. The world of acne treatments can be overwhelming, but Spironolactone is effective for hormonal acne. This blog on Spironolactone for acne covers dosage, administration, and ways to maximize its benefits. This guide helps you confidently manage acne with Spironolactone, especially if you are considering starting it.

How does Spironolactone help hormonal acne?

The anti-androgen medicine Spironolactone inhibits the action of androgens, the hormones that cause the skin to produce more sebum. Spironolactone helps regulate oil production by lowering androgen activity, which helps avoid pore blockage and acne lesion development. Because of this, it works wonders on hormonal acne, which causes deep cystic lesions on the chin and jawline.

Consult a doctor to get Spironolactone to treat your acne.

How to take Spironolactone for acne?

Dealing with hormonal acne, which can be difficult to treat no matter what you do, adds another layer of complexity to the acne treatment landscape. 

Spironolactone has shown great promise among the available options. You must take it correctly to get the most out of Spironolactone for acne. Following are some points you should keep in mind:

  1. Consult your doctor or other healthcare professional to determine the appropriate dosage of Spironolactone for your specific acne condition before beginning treatment.
  1. Never self-adjust the dosage of Spironolactone; doing so increases the risk of side effects and reduces the efficacy of the medication.
  1. Regular testing is required to check renal function and potassium levels to ensure Spironolactone is used safely.
  1. For an effective and personalized acne treatment plan, keeping an open line of communication with your healthcare provider is important. Make sure to report any concerns, side effects, or changes in your health.

Dosage and Administration

Spironolactone is not a conventional acne treatment, but it has helped women with hormonal acne. Acne treatment regimens often include 50–200 mg daily, with 50 mg being the starting point. The dosage can be raised to 200 mg if acne continues. 

According to research on adult female acne, some dermatologists start their patients on 50 mg and gradually increase the dosage to 100–150 mg, depending on how their patients react. 

Always follow your doctor’s dosage instructions precisely, and never take more than recommended. While taking Spironolactone, monitoring your potassium and renal function levels is critical.

Spironolactone formulations

Spironolactone comes in two different forms: tablets and liquid. Most people prefer to take the tablet form, and taking it with food helps with absorption. If you have trouble swallowing pills, you may prefer the liquid form.

A healthcare professional can help you determine the best Spironolactone dose for treating acne.

What happens if I take a double dose of Spironolactone?

Spironolactone side effects, such as electrolyte imbalances, may be more severe if extradoses are consumed. Do not hesitate to consult your doctor or get immediate medical assistance if you overdose on any of your prescribed medications.

How quickly does Spironolactone work for acne?

Spironolactone for acne treatment requires patience. Although some people may notice an improvement after only a few weeks, the full positive effects usually only occur in three to six months. To get the best results, you have to use it consistently.

What are the advantages of using Spironolactone for acne?

The oral administration of spironolactone helps combat hormonal acne, improves skin texture and reduces oiliness.

When should I see a doctor?

Severe adverse effects, such as trouble breathing, swelling, or an irregular heartbeat, require immediate medical intervention. Additionally, if you are worried about the side effects of the medicine or are not experiencing any improvements in your acne, you should talk to your doctor.

Before starting Spironolactone, consult a doctor for personalized treatment!.


By focusing on the specific factors that contribute to hormonal acne, spironolactone has the potential to revolutionize acne treatment. Be patient while you wait for the medication’s revolutionary effects on your skin to take effect, and make sure you follow your healthcare provider’s instructions precisely. A healthcare provider can advise you on the most appropriate dosage and administration method of Spironolactone for acne.

Other questions about Spironolactone

Can you use Spironolactone while trying to conceive?

If you are trying to conceive, you should not take spironolactone because it is unsafe to use while pregnant. For more options on acne treatments that would not harm your unborn child, talk to your doctor.

Can I stop taking Spironolactone once my acne clears up?

Acne may return if you stop taking Spironolactone suddenly. When it is time to stop taking the medication, follow your doctor’s advice.

Are there any dietary restrictions while taking Spironolactone for acne?

Keep a balanced diet and limit your intake of foods high in potassium while taking Spironolactone. If you have any special dietary needs, talk to your doctor about them.

Is Spironolactone only for severe acne cases?

In cases of moderate to severe acne, spironolactone is frequently prescribed, particularly when hormones are involved. If Spironolactone is the right choice for your acne treatment, your doctor will decide after evaluating the severity of your condition.

When can I expect to see results from Spironolactone for acne?

You should start seeing results after a few weeks of regular use, though they might vary. Keep in close contact with your healthcare practitioner, and be patient as you take Spironolactone.

Your Doctors Online uses high-quality and trustworthy sources to ensure content accuracy and reliability. We rely on peer-reviewed studies, academic research institutions and medical associations to provide up-to-date and evidence-based information to the users.

  • Poinas, A., Lemoigne, M., Le Naour, S. et al. FASCE, the benefit of spironolactone for treating acne in women: study protocol for a randomized double-blind trial. Trials 21, 571 (2020). https://doi.org/10.1186/s13063-020-04432-w
  • Charny, J. W., J. K. Choi, and W. D. James. “Spironolactone for the treatment of acne in women, a retrospective study of 110 patients.” International Journal of Women’s Dermatology 3, no. 2 (2017): 111-115.
  • Renz S, Chinnery F, Stuart B, Day L, Muller I, Soulsby I, Nuttall J, Thomas K, Thomas KS, Sach T, Stanton L, Ridd MJ, Francis N, Little P, Eminton Z, Griffiths G, Layton AM, Santer M. Spironolactone for adult female acne (SAFA): protocol for a double-blind, placebo-controlled, phase III randomised study of spironolactone as systemic therapy for acne in adult women. BMJ Open. 2021 Aug 26;11(8):e053876. doi: 10.1136/bmjopen-2021-053876. PMID: 34446504; PMCID: PMC8395279.

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