Does Gabapentin actually help with Sciatica?

Gabapentin for sciatica
Medically reviewed by Dr. Asim Cheema

Overview

Sciatic pain can be excruciating and unbearable. Gabapentin for sciatica is considered alongside NSAIDs including naproxen or ibuprofen, corticosteroids and physical therapy to help in the pain management caused by this condition. To address the following questions keep reading this article:

  • Does Gabapentin help with sciatica nerve pain?
  • What is the Gabapentin dosage for sciatica nerve pain?
Struggling with sciatic pain? Have you exhausted all the OTC painkillers? Consult with our doctor for the best treatment option.

Is Gabapentin good for sciatica?

Gabapentin for low back pain is not typically prescribed. However, those who suffer from numbness, and tingling in the legs from sciatica or nerve pain or have diabetic neuropathy are mainly prescribed Gabapentin. This mechanism of pain relief is based on the drug’s ability to calm the pain signals that are transmitted to the nerves.

Other options include combinations with corticosteroids, and Tylenol.

How does gabapentin work for sciatica?

Gabapentin belongs to the anticonvulsant class of medications that treat pain due to convulsions or nerve damage, especially in the lower back and legs. It works for sciatic pain in several ways, from binding to calcium channels on nerve endings to calming the nerve signals that are hyperactive due to pain and eventually improving pain tolerance for sciatic pain.

Gabapentin work for sciatic pain as follows: 

  • Gabapentin, when absorbed into the body, binds to the calcium channels in the nerve endings that transmit pain signals. It stops the pain signals that help a person feel the pain. Reducing the transmitting frequency decreases the intensity to which pain can be felt. 
  • Gabapentin also helps calm the hyperactive nerves, which also helps in reducing the pain sensation in the area.

Gabapentin helps manage sciatica by calming overactive nerve signals, reducing pain without treating the underlying cause, says Dr.Richard Honekar 

Have you been prescribed Gabapentin for nerve pain? Get your prescription refilled within minutes.

How to take Gabapentin for sciatica?

The normal dosage of Gabapentin for sciatica is 300mg once a day. However, Gabapentin dosage for sciatica nerve pain can be increased up to three times a day depending on the severity of the individual’s condition. It is essential to take the medication as directed and to avoid missing a dose or doubling it. 

This medication is available in the form of a capsule, tablet (immediate release/ extended release), and oral liquid solution.

How long does it take for Gabapentin to work for sciatica?

Gabapentin for sciatica pain can take 1-2 weeks to start showing any noticeable effects. Although, depending on the patient’s condition, dosage and response to the treatment, it may take longer to register relief. The dose may be altered in order to determine the best normal dosage of Gabapentin for sciatica for you. 

What are the side effects of Gabapentin for sciatica?

Gabapentin for sciatica is usually prescribed as a second line when other treatment options fail to work. 

Some common side effects include:

Some uncommon but serious side effects can include:

  • Confusion
  • Trouble breathing
  • Vision changes
  • Suicidal ideation
  • Swelling

Those with breathing problems, particularly conditions such as chronic obstructive pulmonary disease or COPD must practice caution when taking Gabapentin as well as elderly patients as they are more prone to side effects due to decreased kidney function, and poor balance.

Additionally, taking Gabapentin with the following drugs affect your breathing and increase the risk of developing respiratory depression:

  • CNS depressants
  • Opioids
  • Alcohol
Have you run out of Gabapentin? You can get a refill of your prescription by connecting with one of our doctors now!

When to consult a doctor?

Management of Sciatic pain is not simple. This painful condition can wear out the strongest warrior. It is essential that you consult a doctor for pain management options alongside physical therapy. To determine the best treatment options for you and to learn how to manage and treat the pain effectively, talk to one of our doctors at Your Doctors Online.

FAQs gabapentin for sciatica

Does gabapentin heal nerves or just mask pain?

Gabapentin masks the pain rather than healing the nerves by binding to nerve endings where pain signals pass. This reduces the sensation, leading to less pain.

Do you have to take gabapentin every day for nerve pain?

If a healthcare provider prescribes it, yes! It’s essential to follow the prescription guidelines for gabapentin and the recommended dose. Doctors prescribe gabapentin in a pattern of increasing doses to treat sciatic pain effectively. 

What is the best drug for sciatic nerve pain?

NSAIDs, over-the-counter pain relievers, anti-seizure medications, anticonvulsants like gabapentin, and antidepressants are considered the best drugs to treat sciatic nerve pain. However, your healthcare provider can only determine the best drug for your condition after the complete diagnosis. 

Your Doctors Online uses high-quality and trustworthy sources to ensure content accuracy and reliability. We rely on peer-reviewed studies, academic research institutions and medical associations to provide up-to-date and evidence-based information to the users.

  • Giménez-Campos, María Soledad, et al. “A systematic review and meta-analysis of the effectiveness and adverse events of gabapentin and pregabalin for sciatica pain.” Atencion primaria 54.1 (2022): 102144.
  • Robertson, Kelvin, Laurence AG Marshman, and David Plummer. “Pregabalin and gabapentin for the treatment of sciatica.” Journal of Clinical Neuroscience 26 (2016): 1-7.
  • Robertson, Kelvin, et al. “Effect of gabapentin vs pregabalin on pain intensity in adults with chronic sciatica: a randomized clinical trial.” JAMA neurology 76.1 (2019): 28-34.
  • Grice, Gloria R., and Marsha K. Mertens. “Gabapentin as a potential option for treatment of sciatica.” Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 28.3 (2008): 397-402.
  • Mathieson, Stephanie, et al. “Trial of pregabalin for acute and chronic sciatica.” New England Journal of Medicine 376.12 (2017): 1111-1120.
  • Robertson, Kelvin L., and Laurence AG Marshman. “Gabapentin superadded to a pre-existent regime containing amytriptyline for chronic sciatica.” Pain Medicine 17.11 (2016): 2095-2099.

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