How effective is Cymbalta for fibromyalgia

Cymbalta for fibromyalgia
Medically reviewed by Dr. Mandy Liedeman


If you are suffering from pain, fatigue, and sleep disturbances due to fibromyalgia, Cymbalta may be the right solution for you. Fibromyalgia, a complex and often debilitating disorder, afflicts millions of Americans, casting a shadow over their daily lives. Fortunately, emerging treatments provide an effective way to cope with the persistent pain of fibromyalgia. One such ray of hope is Cymbalta, a Food and Drug Administration (FDA) approved medication to address the unique symptoms of fibromyalgia in adults. In this article, we will explore the effectiveness of Cymbalta for fibromyalgia.

Uses of Cymbalta

Here are some of the benefits of Cymbalta:

  • Cymbalta provides rapid and significant pain relief in fibromyalgia, with over half of patients reporting improvement within a week.
  • Noteworthy pain alleviation is observed in individuals with or without coexisting depression.
  • Cymbalta’s positive impact endures for at least three months, contingent on individual responses.
  • Reduced pain facilitates a return to daily routines, enhancing overall quality of life.
  • Improved sleep quality is a direct outcome, potentially aiding in the healing of muscle tissues.
  • Cymbalta, an SNRI (Serotonin-Norepinephrine Reuptake Inhibitor), tends to have fewer bothersome side effects compared to tricyclic antidepressants like amitriptyline, often prescribed for fibromyalgia.
  • FDA approval extends beyond fibromyalgia to include efficacy in major depressive disorder, generalized anxiety disorder, chronic musculoskeletal pain, and diabetic peripheral neuropathy.
Suffering from stiffness and body pain due to fibromyalgia? Cymbalta is an FDA-approved solution for fibromyalgia

While the precise reason for fibromyalgia remains unclear, research shows that repeated nerve stimulation induces changes in the brain. This transformation involves an abnormal increase in specific neurotransmitters, the messengers responsible for signaling pain. Simultaneously, heightened sensitivity in the brain’s pain receptors causes an overreaction to pain signals.

Cymbalta, a key player in managing fibromyalgia, operates by elevating serotonin and norepinephrine levels in the brain. These neurotransmitters play crucial roles in maintaining mental equilibrium and mitigating the transmission of pain signals within neural networks.

Researchers propose that Cymbalta calms these hyperactive pain signals by enhancing serotonin and norepinephrine levels. These naturally occurring substances, dispersed throughout the brain and nervous system, influence mood and are believed to regulate and suppress pain sensations. Cymbalta and other SNRIs hinder the re-entry of serotonin and norepinephrine into cells, amplifying their levels. This delicate process is postulated to uplift mood and alleviate pain, providing relief to fibromyalgia patients.

How Do You Take Cymbalta?

Cymbalta comes in capsule form, designed for once-daily oral intake. The recommended dose is 60 milligrams per day, yet your doctor may advise an initial week at 30 milligrams before progressing to the full dosage. Importantly, exceeding 60 milligrams daily doesn’t offer additional pain reduction and may heighten the risk of side effects.

To minimize the likelihood of stomach upset, consider taking Cymbalta with a meal or some crackers. It’s crucial to refrain from alcohol consumption while on Cymbalta, as doing so could elevate the risk of liver damage.

If you miss a dose, take it as soon as you remember unless it’s close to your next scheduled dose. In such cases, skip the missed dose and resume your regular medication schedule. Never double your dose to compensate.

Abruptly stopping Cymbalta is not advisable, as it may lead to unpleasant side effects such as nausea and headaches. If you discontinue the medication, your doctor will guide you on gradually reducing your dose over time.

If you have any concerns or specific questions regarding the usage of Cymbalta, always consult with your healthcare provider for personalized guidance.

The best time to take Cymbalta is at night if drowsiness is your concern Take it at the same time every day for significant results.

As with any medication, Cymbalta may come with a set of side effects, with the most common ones being the following: 

Additional side effects that may arise include

  • Feelings of jitteriness, nervousness, or restlessness (agitation)
  • Decreased appetite (potentially leading to anorexia)
  • Diminished sex drive
  • Increased sweating 
  • Urinary hesitation
  • Drowsiness

It’s important to note that dizziness upon standing may occur initially or when the dosage is increased, attributed to a drop in blood pressure known as orthostatic hypotension. Your healthcare provider may monitor your blood pressure periodically throughout your Cymbalta treatment.

If you experience any of these effects persistently or if they become bothersome, discussing them with your healthcare provider is advised. 

Before taking Cymbalta, providing your doctor with a comprehensive overview of your medical history is crucial. The medication should be approached with caution if you have:

  • Conditions associated with slowed gastric emptying (common in diabetic patients)
  • Diabetes, as Cymbalta may influence blood sugar levels
  • High blood pressure or heart disease
  • A history of seizures or mania
  • Pre-existing liver disease
  • Kidney disease

These considerations ensure a tailored and cautious approach to using Cymbalta for fibromyalgia, considering your health profile. Open and transparent communication with your healthcare provider is key to ensuring the safest and most effective treatment plan for your specific circumstances. 


In the landscape of fibromyalgia treatment, several alternatives exist beyond Cymbalta. 

  • An SNRI approved for fibromyalgia is Savella (milnacipran), which offers a different approach to symptom management. 
  • Lyrica (pregabalin), initially designed for epilepsy and nerve pain, has gained approval for fibromyalgia treatment.
  • Off-label use of venlafaxine (Effexor), which is also SNRI. 

Your healthcare provider may also consider various alternatives, including:

  • Over-the-counter pain relievers such as acetaminophen (Tylenol) and ibuprofen (Advil, Motrin)
  • Anti-seizure drugs, with gabapentin (Neurontin) as a notable option
  • Prescription pain relievers like tramadol (Ultram)

Cymbalta is just one among several choices for treating and managing fibromyalgia. Your healthcare provider will guide you in selecting the most suitable approach based on your health needs and preferences.

Not sure whether Cymbalta is the right fit  as per your medical history? Consult with a provider now.

When to See a Doctor

Ensuring the effectiveness and safety of Cymbalta in your fibromyalgia treatment requires proactive communication with your healthcare provider. Reach out to your doctor if:

  • Your fibromyalgia symptoms worsen while on Cymbalta
  • You contemplate a change in your medication
  • You inadvertently miss a dose of Cymbalta

Additionally, prompt medical attention is crucial if you encounter more severe side effects of Cymbalta, such as hallucinations, high fevers, or intense mood swings. If you have any concerns or experience changes in your condition, do not hesitate to seek professional guidance.

Other FQAs bout Cymbalta for fibromyalgia

What is the best drug for fibromyalgia pain?

Medications approved by the FDA for fibromyalgia pain relief include Duloxetine (Cymbalta), Milnacipran (Savella), and Pregabalin (Lyrica). Some medications are used “off-label,” indicating that although not FDA-approved for fibromyalgia, doctors may prescribe them based on observed benefits.

What is the newest treatment for fibromyalgia?

Emerging treatments encompass mind-body techniques like biofeedback, hypnosis, and cognitive-behavioral therapy (CBT). Research suggests their efficacy, particularly when incorporated into a multidisciplinary treatment approach.

Does Cymbalta help with pain and fatigue?

Cymbalta (duloxetine), FDA-approved for fibromyalgia management in adults, proves an effective solution in the treatment of pain and fatigue caused by fibromyalgia.

When is the best time to take Cymbalta for fibromyalgia?

Consistency in daily intake is crucial. If drowsiness is a concern, taking the medication at night may be preferable. The key is to maintain a regular schedule for optimal effectiveness.

Your Doctors Online uses high-quality and trustworthy sources to ensure content accuracy and reliability. We rely on peer-reviewed studies, academic research institutions and medical associations to provide up-to-date and evidence-based information to the users.

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  • Migliorini, F., Maffulli, N., Eschweiler, J. et al. Duloxetine for fibromyalgia syndrome: a systematic review and meta-analysis. J Orthop Surg Res 18, 504 (2023).
  • Migliorini F, Maffulli N, Eschweiler J, Baroncini A, Bell A, Colarossi G. Duloxetine for fibromyalgia syndrome: a systematic review and meta-analysis. J Orthop Surg Res. 2023 Jul 17;18(1):504. doi: 10.1186/s13018-023-03995-z. PMID: 37461044; PMCID: PMC10351165.
  • Arnold, Lesley M. “Duloxetine and other antidepressants in the treatment of patients with fibromyalgia.” Pain medicine 8, no. suppl_2 (2007): S63-S74.

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