Azithromycin for COVID Treatment: What You Need to Know

azithromycin for covid
Medically reviewed by Dr. Mavra Farrukh

Key Takeaways

  • Azithromycin, particularly when administered at the right dosage and time, can be an effective treatment for COVID-19.
  • Although Azithromycin is generally well-tolerated, there are a few side effects that you should be aware of.
  • Given the evolving nature of COVID-19 and individual health conditions, it is imperative to consult with healthcare providers before starting any treatment regimen involving Azithromycin.


One antibiotic that attracted a lot of attention as a potential treatment for COVID-19 was Azithromycin. This blog covers the uses of Azithromycin, Zpack, and Zithromax in fighting against the infection. We must grasp the larger picture of antibiotics in treating superimposed bacterial infections as we investigate their potential use in COVID-19 treatment. To help you make informed decisions about using Azithromycin, we will also address safety concerns and potential side effects.

If you need Azithromycin for COVID-19 and other infections. Consult a doctor now!

Is it safe to take Azithromycin for COVID-19?

There has been some speculation that Azithromycin, sold under the brand names Zithromax and Z-Pack, could be useful in treating COVID-19. While generally considered safe for its approved indications, the studies suggest Azithromycin might be a viable option for specific patient groups when part of usual care. Despite its rapid adoption for COVID-19 treatment without high-quality evidence, uncertainties persist. 

Consulting a healthcare professional is crucial for the most accurate guidance, and formal clinical trials are recommended to establish the efficacy and safety of Azithromycin in treating COVID-19.

How to take Azithromycin for COVID-19?

Many studies have analyzed Azithromycin and its effects on COVID-19, but opinions on how to use it vary. Doctors suggest a 5-day course with a 500 mg dose on day 1 and 250 mg for the next four days. Some doctors also agree on recommending 500 mg of Azithromycin orally once daily for three days alongside standard treatment. Regardless of these recommendations, to get the most accurate and current guidance on using Azithromycin for COVID-19, it is imperative to consult a healthcare professional.

What is the best time to take Zpack for COVID-19?

A healthcare provider typically determines the timing of Azithromycin (Z-Pack) administration for COVID-19. It is essential to adhere strictly to the prescribed dosage and schedule. Generally, Azithromycin may be taken with or without food, but individual instructions may vary. Consult your healthcare professional for personalized advice.

How long does Azithromycin take to work for COVID-19?

The efficacy of azithromycin in combating COVID-19 remains debatable. When it comes to treating bacterial infections, azithromycin is the antibiotic of choice. Its potential role in COVID-19 treatment is being studied, but limited evidence supports its efficacy against the virus. 

Azithromycin impacts specific cellular pathways in your body, such as the MAPK and NF-κB pathways. Mucin secretion, inflammation, and cell proliferation are just a few of the many processes that rely on these pathways. Azithromycin exerts its effects on these pathways. 

This is primarily why, Azithromycin is so useful in treating exacerbation of conditions including cystic fibrosis, bronchiectasis, COPD, chronic rhinosinusitis, sepsis, and diffuse panbronchiolitis, among other chronic lung diseases.

If you are experiencing symptoms of COVID-19. You can consult a doctor online about treatment.

How can you manage Azithromycin’s side effects?

Azithromycin, like any medicine, might cause unwanted effects. Side effects such as these are common: stomach pain, vomiting, diarrhea, and nausea. Azithromycin is best taken with food to lessen the severity of these side effects. Talk to your doctor if you experience any worsening or persistent side effects. Please notify us right away if you experience any serious side effects.

What are the limitations and criticisms about Azithromycin used for COVID?

The use of Azithromycin for COVID-19 is subject to limitations and criticisms. Some studies have questioned its effectiveness, and there are concerns about potential side effects and antibiotic resistance. The scientific community continues to investigate and analyze the role of Azithromycin in COVID-19 treatment, and recommendations may change as more evidence becomes available.

When to consult a doctor?

Consult a doctor if you experience any adverse effects while taking Azithromycin for COVID-19 or if your symptoms persist or worsen. You should always consult a doctor before beginning a new treatment or medication.

Other questions about Azithromycin

Is Azithromycin good for COVID-19?

The efficacy of Azithromycin in treating COVID-19 is still unclear and subject to ongoing research. It is essential to rely on information from reputable health organizations and consult with healthcare professionals for guidance on COVID-19 treatments.

Can I take Azithromycin and Amoxicillin together for COVID-19?

Combining Azithromycin and Amoxicillin for COVID-19 treatment is not a standard practice, and the safety and efficacy of such combinations need to be well-established. Always consult a healthcare provider instead of self-medicating.

Can I take Doxycycline and Azithromycin together for COVID?

Only a doctor should prescribe Azithromycin to a patient with COVID-19.. Self-medicating or mixing medications without a doctor’s advice because of the potential for side effects is not recommended.

How long can I take Zpack for COVID?

After considering the patient’s specific circumstances, a healthcare professional should determine the duration of Azithromycin (Z-Pack) use for COVID-19. It is essential to complete the prescribed course of medication and consult a doctor before extending or altering the duration. Taking a 500mg dose followed by a 250mg dosage per day for four days is recommended.

Do antibiotics help when you have COVID-19?

COVID-19 is caused by a virus, not bacteria, so antibiotics are ineffective in treating the viral infection. Antibiotics may be prescribed for a secondary bacterial infection, but their use for COVID-19 treatment is limited. Azithromycin is also prescribed for a bacterial infection that can follow after COVID-19 or to prevent the worsening of the infection.

Can Azithromycin be used as a standalone treatment for COVID-19?

The use of Azithromycin as a standalone treatment for COVID-19 is recommended with proper medical supervision. Current guidelines and research suggest a multifaceted approach to COVID-19 treatment, and Azithromycin, if prescribed, is often part of a combination therapy.

Is Azithromycin commonly used in combination with other medications for COVID-19 treatment?

Azithromycin is sometimes prescribed in combination with other medications for COVID-19 treatment, depending on the severity of symptoms and individual patient characteristics. The decision to use combination therapy should be made by healthcare professionals based on the latest evidence and guidelines.

Your Doctors Online uses high-quality and trustworthy sources to ensure content accuracy and reliability. We rely on peer-reviewed studies, academic research institutions and medical associations to provide up-to-date and evidence-based information to the users.

Echeverría-Esnal, D., Martin-Ontiyuelo, C., Navarrete-Rouco, M. E., De-Antonio Cuscó, M., Ferrández, O., Horcajada, J. P., & Grau, S. (2021). Azithromycin in the treatment of COVID-19: a review. Expert review of anti-infective therapy19(2), 147-163.

Sultana, J., Cutroneo, P. M., Crisafulli, S., Puglisi, G., Caramori, G., & Trifirò, G. (2020). Azithromycin in COVID-19 patients: pharmacological mechanism, clinical evidence and prescribing guidelines. Drug safety43, 691-698.

RECOVERY Collaborative Group. (2021). Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. Lancet (London, England)397(10274), 605.

Gyselinck, I., Janssens, W., Verhamme, P., & Vos, R. (2021). Rationale for azithromycin in COVID-19: an overview of existing evidence. BMJ Open Respiratory Research8(1), e000806.

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