Why am i not losing weight on wegovy?

why am i not losing weight on wegovy
Medically reviewed by Richard Honaker M.D.


Wegovy is an FDA-approved injectable medication for weight management that should be used under the guidance of a healthcare provider to ensure proper dosage and administration. Despite its promising results, Wegovy’s effectiveness can vary due to genetics, underlying health conditions, and insufficient lifestyle changes. Developing a comprehensive weight management plan with a healthcare provider and incorporating diet, exercise, hydration, and regular follow-up visits are crucial. Worried about why you are not losing weight on wegovy? While clinical trials have shown Wegovy to be effective for many, some individuals may not experience significant weight loss or may hit a weight loss plateau. This can occur due to inconsistent medication use, insufficient lifestyle modifications, or genetic predispositions.

Why am I not losing weight on Wegovy?

Wegovy is a powerful and effective FDA-approved medication for weight management, but sometimes it doesn’t yield the expected results. Developed by Novo Nordisk, Wegovy contains semaglutide, a GLP-1 receptor agonist that mimics a hormone to reduce appetite and food intake. Around 10% to 15% of people on Wegovy don’t lose weight, though they may still benefit from other health improvements. There are various reasons why this might happen, ranging from medication-related issues to lifestyle factors and underlying health conditions. Here, we explore some potential reasons why you might not lose weight on Wegovy and what you can do about it.

1. Incorrect dosage

One critical factor for Wegovy’s effectiveness is ensuring the correct dosage. The treatment usually begins with a lower dose of 0.25 milligrams (mg) once weekly, gradually increasing to a maintenance dose of 1.7 or 2.4 mg over several weeks. Staying on a lower dose for too long can limit weight loss. Working closely with your healthcare provider to adjust the dose appropriately is essential if you’re not seeing results.

2. Incorrect administration

Proper administration of Wegovy is crucial for its effectiveness. The medication should be injected under the skin once a week on the same day, ensuring the pen is pressed firmly against the skin until the yellow bar stops moving. Rotating the injection site can also help prevent skin irritation. Following the instructions on the medication package and those given by your healthcare provider is essential for maximum effectiveness.

3. Improper storage

Wegovy should be stored in the refrigerator when not in use. It can be stored at room temperature for up to 28 days. However, exposure to extreme temperatures can reduce its effectiveness. Ensuring proper storage conditions is vital for maintaining the medication’s potency.

Wegovy is not giving you the desired results? You should revisit your dosage and administration method.

3. Individual genetic differences

Genetic makeup can influence how well Wegovy works. Variants in the gene that codes for the GLP-1 receptor, the drug’s target, can affect weight loss outcomes. If you suspect genetic factors might be influencing your response to Wegovy, consult your healthcare provider about the possibility of genetic testing.

4. Weight-loss plateau

It’s common to experience a weight-loss plateau over time, even with consistent medication use, diet, and exercise. This plateau can occur as your body adapts to the medication. If you hit a plateau, your healthcare provider might recommend adjusting your treatment plan, such as trying a different medication or modifying your lifestyle further.

5. Inadequate duration of treatment

Weight loss with Wegovy is typically gradual, and it can take several weeks or months to see significant changes. Clinical trials showed that many patients didn’t reach maximum weight loss until 68 weeks of treatment. Patience and adherence to the medication schedule are crucial.

6. Underlying health conditions

Conditions like hypothyroidism, polycystic ovary syndrome (PCOS), and hormonal imbalances can hinder weight loss. Additionally, mental health issues such as depression and anxiety can affect your motivation and consistency in taking Wegovy. Managing these underlying conditions with the help of a healthcare provider is essential to achieve optimal results.

7. Chronic stress

Prolonged stress can increase cortisol levels, leading to fat storage around the abdomen and an increased appetite for unhealthy foods. Stress management techniques like mindfulness, exercise, and adequate sleep can help mitigate these effects.

If you are doing everything right and still not losing weight Maybe stress is not letting you lose weight

8. Lack of sleep

Insufficient sleep can disrupt hormones that regulate hunger and metabolism, increasing cravings and appetite. Aim for 7-8 hours of quality sleep each night. Good sleep hygiene practices, such as maintaining a regular sleep schedule and reducing screen time before bed, can support weight loss efforts.

9. Other medications

Certain medications, including some antipsychotics, antidepressants, anti-seizure drugs, steroids, and diabetes medications, can contribute to weight gain or hinder weight loss. If you suspect your medications might be affecting your weight, discuss alternative options with your healthcare provider.

10. Nutritional and exercise factors

Even with Wegovy, maintaining a healthy, reduced-calorie diet and regular exercise is essential. Avoid high-calorie, high-fat, and high-sugar foods, and ensure you get at least 150 minutes of moderate-intensity aerobic activity per week. Consulting with a dietitian or nutritionist can help tailor a diet plan to your specific needs.

Several factors can influence Wegovy’s success in weight loss. By taking a holistic approach and addressing any underlying conditions, you can improve your chances of achieving your weight loss goals with Wegovy.

What are the common mistakes when using Wegovy for weight loss?

If you are wondering why am i gaining weight on wegovy, you might want to revisit your daily routine. Many people make preventable mistakes when using Wegovy for weight loss, often due to a lack of guidance and support.

1. Not sticking to dietary changes

Even with Wegovy, achieving weight loss generally requires maintaining a calorie deficit. Consuming high-calorie foods and sugary beverages can counteract the medication’s benefits. Healthy dietary habits, including eating whole foods and balancing nutrient intake, are essential for weight loss.

2. Lack of regular exercise

Regular physical activity is crucial when using Wegovy. Exercise helps burn calories and supports overall health, making it a vital component of any weight loss plan. Without consistent exercise, weight loss results may be slower, and plateaus can occur, undermining Wegovy’s effectiveness.

3. Inconsistent use of the medication or missing doses

Consistency is key when taking Wegovy. The medication regulates appetite by stimulating a hormone that helps you feel full sooner. Missing doses or taking the medication inconsistently can reduce its effectiveness, leading to less optimal weight loss results.

4. Overlooking the importance of hydration

Proper hydration is vital to weight loss. Hydration influences metabolism; even slight dehydration can reduce metabolic rates and affect energy balance. Individuals with higher body mass indexes (BMIs) are more prone to inadequate hydration, hindering weight loss efforts.

5. Skipping follow-up appointments with healthcare providers

Regular follow-ups with healthcare providers are crucial for tracking progress and adjusting treatment plans. Skipping these appointments can result in suboptimal outcomes, as ongoing medical supervision helps set realistic goals and maintain momentum in the weight loss journey.

6. Discontinuing the medication prematurely

Stopping Wegovy without medical guidance can lead to suboptimal results. Some individuals may discontinue use due to side effects or lack of immediate weight loss. However, Wegovy’s benefits typically manifest over a sustained period, and abrupt discontinuation can impede progress.

Avoiding these common mistakes can improve your chances of success with Wegovy. Proper guidance, adherence to lifestyle changes, and regular medical supervision are essential for achieving the best weight loss results. 

Weight loss medications are only taken and withdrawn as per doctor’s advice. Consultation can help you see effective results in real-time

How do you maximize the results of Wegovy?

If you want to maximize weight loss while on Wegovy, incorporating several strategies into your treatment plan can enhance your outcomes. Here are 5 ways to increase weight loss on wegovy:

1. Seek support for psychological issues

Managing underlying psychological factors is crucial for long-term success with Wegovy. Emotional eating and stress can disrupt weight loss efforts. If you’re experiencing depression, anxiety, or other mental health disorders affecting your appetite, consider therapy or support groups to manage these challenges effectively.

2. Gradually increase physical activity

Physical activity is essential for losing weight and maintaining muscle mass. Start slowly and gradually increase the intensity of your workouts. Combining strength training with aerobic exercises can boost energy levels and improve overall health. Aim for at least 150 minutes of moderate-intensity exercise per week.

3. Use a food journal for tracking

Keeping a food journal can help you monitor dietary habits and calorie intake, making identifying patterns that might hinder your weight loss goals easier. This practice allows you to make necessary dietary adjustments and stay on track with your nutrition plan.

4. Plan meals in advance

Planning meals can prevent impulsive eating and ensure a balanced, nutritious diet. Having a set plan reduces the likelihood of consuming extra, unnecessary calories. Focus on eating whole foods and maintaining a high-protein diet to regulate blood sugar levels and manage hunger effectively.

5. Celebrate small victories

Recognizing and celebrating small signs of progress can help keep you motivated throughout your weight loss journey. Acknowledge any achievements, no matter how minor, to maintain a positive mindset and stay committed to your goals.

If you miss your Wegovy dose and your next scheduled dose is more than two days (48 hours) away, take the missed dose as soon as possible. If it’s less than two days away, skip the missed dose and continue your regular dosing schedule. If you miss two or more doses, consult your healthcare provider. They may recommend resuming your usual schedule or restarting Wegovy with the dose escalation schedule to minimize stomach symptoms. Staying on track and maintaining your routine is key without doubling up on doses.

How fast do you lose weight on Wegovy?

Wegovy, a GLP-1 weight-loss medication, can facilitate rapid weight loss for many individuals. However, if you want to know how long you have to wait to see results from wegovy, most people can expect to lose more than 5% of their body weight within the first three months of treatment. For example, if you weigh 200 pounds, you might lose 10 pounds within this period. Long-term weight loss expectations are as follows:

  • People without diabetes: On average, individuals without diabetes may lose about 15% of their body weight after 16 months of using Wegovy.
  • People with diabetes: Those with diabetes typically experience an average weight loss of around 10% of their body weight after 16 months.

It’s important to remember that these figures are averages. Some people may lose significantly more weight, while others may lose less. 

If you have been using Wegovy for over three months and haven’t lost at least 5% of your body weight, you may be considered a “nonresponder” to the medication. This classification means that Wegovy isn’t working as effectively for you as it does for others, but it doesn’t imply you’re doing anything wrong. Bodies respond differently to medications. If you find yourself in this situation, it’s advisable to consult your healthcare professional to discuss alternative medications or approaches to weight loss.

Are there alternatives to Wegovy?

If wegovy is not working for you, there are other alternatives you can explore for weight loss. Wegovy is a popular weight loss medication, but it’s not the only option available. If you’re not seeing the desired results, your healthcare provider might adjust your dosage or suggest an alternative medication. Other FDA-approved weight loss medications that might be considered include:

  • Saxenda (liraglutide): This medication is another GLP-1 receptor agonist that can help with weight loss. It works similarly to Wegovy and might be more effective for some individuals.
  • Zepbound (tirzepatide): This newer medication targets GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors. It has shown promise in weight loss and might be a better fit for some patients.

It is important to discuss these options with your healthcare provider to understand the potential benefits, drug interactions, and side effects of each alternative. They can help you determine the best action based on your health needs and weight loss goals.

What do you do if you’re not losing weight on Wegovy?

If you’re taking Wegovy and do not see the desired weight loss despite maintaining healthy habits, here are some steps to consider:

Health screening

Your provider may screen you for other health conditions affecting your weight loss. Conditions such as hypothyroidism, polycystic ovary syndrome (PCOS), or other metabolic disorders can impact your ability to lose weight.

Medication review

Inform your provider about all the medications you are currently taking, as some medications can contribute to weight gain or hinder weight loss. Your provider can help you understand any potential interactions and may suggest alternatives.

Dosage adjustment

Your provider might consider adjusting your Wegovy dosage. Sometimes, a higher dose might be necessary to achieve the desired results.

Evaluate lifestyle factors

  • Diet and exercise: Follow a balanced, reduced-calorie diet and incorporate regular physical activity into your routine. Sometimes, adjustments to a small diet or exercise plan can make a significant difference.
  • Sleep and stress management: Adequate sleep and stress management are crucial for weight loss. Poor sleep and high stress levels can interfere with these efforts.

Consult a doctor

Initial prescription criteria:

  • High BMI: BMI of 30 or more.
  • BMI with Weight-Related Conditions: BMI of 27 or more with conditions like high blood cholesterol, high triglyceride levels, or high blood pressure.

Experiencing side effects:

  • Diarrhea: Contact your doctor or pharmacist. They might suggest OTC treatments like Imodium (loperamide).
  • Other Side Effects: Report any other unusual symptoms.

Monitoring progress:

  • Regular Appointments: Maintain regular check-ups to monitor progress, get support, and adjust the treatment plan.
  • Weight Loss Milestones: If you haven’t lost at least 5% of your body weight after three months, consult your doctor.

Optimizing treatment:

  • Lifestyle adjustments: Work with your healthcare provider on dietary changes, physical activity, and behavioral modifications.
  • Treatment plan adjustments: Discuss any necessary changes to improve your weight loss results.


Is it normal not to lose weight in the first couple of weeks on Wegovy?

Yes, it is normal. Many people do not start seeing visible weight loss effects of Wegovy until around the 20-week mark. If you are frustrated by not losing weight initially, consider how long you’ve been using the medication. It’s advisable to consult your provider if it has been over 20 weeks without noticeable results.

What happens when you stop taking Wegovy?

Most people do not keep all the weight off after stopping semaglutide (Wegovy) and may regain some of the lost weight. The amount of weight regained can vary among individuals and may depend on factors such as age, health history, dietary habits, and other environmental factors.

What is the average weight loss per month on Wegovy?

For someone with a starting weight of 200 pounds, the expected weight loss might be about 4 pounds per month. Clinical trials have shown an average of approximately 6% weight reduction after 12 weeks and 10% after 20 weeks. This is the average weight loss experienced by people using Wegovy for weight management.

Do people always lose weight on Wegovy?

While most people lose weight after taking Wegovy, some (about 10% to 15%) do not. However, this does not necessarily mean the medication hasn’t been helping in other ways, such as improving metabolic health or managing appetite.

Your Doctors Online uses high-quality and trustworthy sources to ensure content accuracy and reliability. We rely on peer-reviewed studies, academic research institutions and medical associations to provide up-to-date and evidence-based information to the users.

  • Singh, Gurdeep, Matthew Krauthamer, and Meghan Bjalme-Evans. “Wegovy (semaglutide): a new weight loss drug for chronic weight management.” Journal of Investigative Medicine 70.1 (2022): 5-13.
  • Prillaman, McKenzie. “Obesity drugs aren’t always forever. What happens when you quit?.” Nature 628.8008 (2024): 488-490.
  • Altywaiq, Abdullah Mohammed, et al. “Ozempic and Wegovy for Weight Loss, Pharmacological Component and Effect.” Journal of Namibian Studies: History Politics Culture 31 (2022): 167-180.
  • Phillips, Anna, and Jennifer N. Clements. “Clinical review of subcutaneous semaglutide for obesity.” Journal of clinical pharmacy and therapeutics 47.2 (2022): 184-193.
  • Slim, Lynne H. “Understanding Ozempic and Wegovy, the Drugs at the Center of the Latest Weight Loss Craze.”

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